Fumitoshi Satoh1, Ryo Morimoto2, Kazumasa Seiji2, Nozomi Satani2, Hideki Ota2, Yoshitsugu Iwakura2, Yoshikiyo Ono2, Masataka Kudo2, Masahiro Nezu2, Kei Omata3, Yuta Tezuka3, Yoshihide Kawasaki2, Shigeto Ishidoya2, Yoichi Arai2, Kei Takase2, Yasuhiro Nakamura2, Keely McNamara2, Hironobu Sasano2, Sadayoshi Ito2. 1. Division of Clinical HypertensionEndocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, JapanDivision of NephrologyEndocrinology and Vascular Medicine, Department of MedicineDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of PathologyTohoku University Hospital, Sendai, Miyagi 980-8574, Japan Division of Clinical HypertensionEndocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, JapanDivision of NephrologyEndocrinology and Vascular Medicine, Department of MedicineDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of PathologyTohoku University Hospital, Sendai, Miyagi 980-8574, Japan fsatoh@med.tohoku.ac.jp. 2. Division of Clinical HypertensionEndocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, JapanDivision of NephrologyEndocrinology and Vascular Medicine, Department of MedicineDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of PathologyTohoku University Hospital, Sendai, Miyagi 980-8574, Japan. 3. Division of Clinical HypertensionEndocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, JapanDivision of NephrologyEndocrinology and Vascular Medicine, Department of MedicineDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of PathologyTohoku University Hospital, Sendai, Miyagi 980-8574, Japan Division of Clinical HypertensionEndocrinology and Metabolism, Tohoku University Graduate School of Medicine, Sendai, Miyagi, JapanDivision of NephrologyEndocrinology and Vascular Medicine, Department of MedicineDepartment of Diagnostic RadiologyDepartment of UrologyDepartment of PathologyTohoku University Hospital, Sendai, Miyagi 980-8574, Japan.
Abstract
OBJECTIVE AND DESIGN: Adrenal venous sampling (AVS) is critical to determine the subtype of primary aldosteronism (PA). Central AVS (C-AVS)--that is, the collection of effluents from bilateral adrenal central veins (CV)--sometimes does not allow differentiation between bilateral aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism. To establish the best treatment course, we have developed segmental AVS (S-AVS); that is, we collect effluents from the tributaries of CV to determine the intra-adrenal sources of aldosterone overproduction. We then evaluated the clinical utility of this novel approach in the diagnosis and treatment of PA. METHODS: We performed C-AVS and/or S-AVS in 297 PA patients and assessed the accuracy of diagnosis based on the results of C-AVS (n=138, 46.5%) and S-AVS (n=159, 53.5%) by comparison with those of clinicopathological evaluation of resected specimens. RESULTS: S-AVS demonstrated both elevated and attenuated secretion of aldosterone from APA and non-tumorous segments, respectively, in patients with bilateral APA and recurrent APA. These findings were completely confirmed by detailed histopathological examination after surgery. S-AVS, but not C-AVS, also served to identify APA located distal from the CV. CONCLUSIONS: Compared to C-AVS, S-AVS served to identify APA in some patients, and its use should expand the pool of patients eligible for adrenal sparing surgery through the identification of unaffected segments, despite the fact that S-AVS requires more expertise and time. Especially, this new technique could enormously benefit patients with bilateral or recurrent APA because of the preservation of non-tumorous glandular tissue.
OBJECTIVE AND DESIGN: Adrenal venous sampling (AVS) is critical to determine the subtype of primary aldosteronism (PA). Central AVS (C-AVS)--that is, the collection of effluents from bilateral adrenal central veins (CV)--sometimes does not allow differentiation between bilateral aldosterone-producing adenomas (APA) and idiopathic hyperaldosteronism. To establish the best treatment course, we have developed segmental AVS (S-AVS); that is, we collect effluents from the tributaries of CV to determine the intra-adrenal sources of aldosterone overproduction. We then evaluated the clinical utility of this novel approach in the diagnosis and treatment of PA. METHODS: We performed C-AVS and/or S-AVS in 297 PA patients and assessed the accuracy of diagnosis based on the results of C-AVS (n=138, 46.5%) and S-AVS (n=159, 53.5%) by comparison with those of clinicopathological evaluation of resected specimens. RESULTS: S-AVS demonstrated both elevated and attenuated secretion of aldosterone from APA and non-tumorous segments, respectively, in patients with bilateral APA and recurrent APA. These findings were completely confirmed by detailed histopathological examination after surgery. S-AVS, but not C-AVS, also served to identify APA located distal from the CV. CONCLUSIONS: Compared to C-AVS, S-AVS served to identify APA in some patients, and its use should expand the pool of patients eligible for adrenal sparing surgery through the identification of unaffected segments, despite the fact that S-AVS requires more expertise and time. Especially, this new technique could enormously benefit patients with bilateral or recurrent APA because of the preservation of non-tumorous glandular tissue.
Authors: Kazutaka Nanba; Kei Omata; Celso E Gomez-Sanchez; Constantine A Stratakis; Andrew P Demidowich; Mari Suzuki; Lester D R Thompson; Debbie L Cohen; James M Luther; Lan Gellert; Anand Vaidya; Justine A Barletta; Tobias Else; Thomas J Giordano; Scott A Tomlins; William E Rainey Journal: Hypertension Date: 2019-04 Impact factor: 10.190
Authors: R Morimoto; N Satani; Y Iwakura; Y Ono; M Kudo; M Nezu; K Omata; Y Tezuka; K Seiji; H Ota; Y Kawasaki; S Ishidoya; Y Nakamura; Y Arai; K Takase; H Sasano; S Ito; F Satoh Journal: J Hum Hypertens Date: 2015-11-05 Impact factor: 3.012