Literature DB >> 26193207

Proximal tibial osteosarcoma in young patients: early diagnosis, modular reconstruction.

Răzvan Ene1, Ruxandra Diana Sinescu, Patricia Ene, Dan Popescu, Monica Mihaela Cîrstoiu, Florin Cătălin Cîrstoiu.   

Abstract

Osteosarcoma is the most common bone tumor that occurs in children and young adults with prevalence of teenage. There can be identified many subtypes of osteosarcoma by how they look on X-rays and under the microscope. Osteosarcoma can be classified as high-grade, intermediate grade, or low-grade. This has a significant prognostic value of tumor development suggesting the growth rate and the potential for expansion. Between 2009-2013, in the Department of Orthopedics and Traumatology, University Emergency Hospital of Bucharest, Romania, were treated seven cases of osteosarcoma of the proximal third of the tibia in young, early-diagnosed cases without metastasis. The treatment involved resection of tumor formation and reconstruction with a modular prosthesis. Postoperative patients were mobilized for a week without charging the operated limb under the protection of orthesis. During this period continued active and passive mobilization of the ankle and foot to prevent stiffness and to reduce postoperative swelling. From the second postoperative week, patients are mobilizing with progressive charging but not being allowed to do any flexion in order to protect de insertion of medial gastrocnemius muscle rotation flap used to cover the prosthesis and to protect the patellar tendon reinsertion. This extensive surgery does not improve survival rate of these patients compared to treatment by amputation of this pathology but greatly increases the comfort of life and in all cases ensure socio-professional reintegration of these patients. To ensure optimal postoperative results perform a complete diagnosis and preoperative oncological treatment before surgery, if applicable.

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Mesh:

Year:  2015        PMID: 26193207

Source DB:  PubMed          Journal:  Rom J Morphol Embryol        ISSN: 1220-0522            Impact factor:   1.033


  6 in total

1.  Proximal humerus chondrosarcoma in a young male patient.

Authors:  Răzvan Ene; Florin Cătălin Cîrstoiu; Mihai Nica; Zsombor Alpár Pánti; Corina Panaitescu; Elisa Popescu; Adrian Vasile Dumitru; Irina Anca Eremia; Adrian Cursaru; Dragoş Ene
Journal:  Rom J Morphol Embryol       Date:  2020 Jul-Sep       Impact factor: 1.033

2.  The Function of the Novel Mechanical Activated Ion Channel Piezo1 in the Human Osteosarcoma Cells.

Authors:  Long Jiang; Yi-Ding Zhao; Wei-Xiang Chen
Journal:  Med Sci Monit       Date:  2017-10-24

3.  miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3β/β-catenin signaling pathway.

Authors:  Chun Zhou; Chang-Qing Jiang; Zhen Zong; Jia-Chen Lin; Li-Feng Lao
Journal:  Oncotarget       Date:  2017-07-19

Review 4.  Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment.

Authors:  Razvan Ene; Mihai Nica; Dragos Ene; Adrian Cursaru; Catalin Cirstoiu
Journal:  EFORT Open Rev       Date:  2021-05-04

5.  The multidisciplinary treatment of osteosarcoma of the proximal tibia: a retrospective study.

Authors:  Junqi Huang; Wenzhi Bi; Gang Han; Jinpeng Jia; Meng Xu; Wei Wang
Journal:  BMC Musculoskelet Disord       Date:  2018-09-05       Impact factor: 2.362

6.  Construction and Validation of Nomograms for Predicting the Prognosis of Juvenile Osteosarcoma: A Real-World Analysis in the SEER Database.

Authors:  Yao Jiang; Tianyu Wang; Zizheng Wei
Journal:  Technol Cancer Res Treat       Date:  2020 Jan-Dec
  6 in total

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