Literature DB >> 2619282

Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol.

T S Lin1, R Schinazi, B P Griffith, E M August, B F Eriksson, D K Zheng, L A Huang, W H Prusoff.   

Abstract

The (-) enantiomer of gossypol but not the (+) enantiomer had good antiviral activity in peripheral blood mononuclear cells against human immunodeficiency virus type 1 at a concentration more than 20-fold lower than that required for cytotoxicity; however, in H9 cells the (-) enantiomer, although more potent as an antiviral agent, was more cytotoxic.

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Year:  1989        PMID： 2619282      PMCID： PMC172840          DOI： 10.1128/AAC.33.12.2149

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Letter: Antiviral activity of gossypol and apogossypol.

Authors:  P H Dorsett; E E Kerstine; L J Powers
Journal:  J Pharm Sci       Date:  1975-06       Impact factor: 3.534

2.  Resolution of racemic gossypol.

Authors:  D K Zheng; Y K Si; J K Meng; J Zhou; L Huang
Journal:  J Chem Soc Chem Commun       Date:  1985-02-01

Review 3.  Physiological effects and metabolism of gossypol.

Authors:  M B Abou-Donia
Journal:  Residue Rev       Date:  1976

4.  Inhibition of growth of human immunodeficiency virus in vitro by crude extracts of Chinese medicinal herbs.

Authors:  R S Chang; H W Yeung
Journal:  Antiviral Res       Date:  1988-04       Impact factor: 5.970

5.  Combinations of isoprinosine and 3'-azido-3'-deoxythymidine in lymphocytes infected with human immunodeficiency virus type 1.

Authors:  R F Schinazi; D L Cannon; B H Arnold; D Martino-Saltzman
Journal:  Antimicrob Agents Chemother       Date:  1988-12       Impact factor: 5.191

6.  Comparison of inhibitory activities of various antiretroviral agents against particle-derived and recombinant human immunodeficiency virus type 1 reverse transcriptases.

Authors:  R F Schinazi; B F Eriksson; S H Hughes
Journal:  Antimicrob Agents Chemother       Date:  1989-01       Impact factor: 5.191

7.  [Study of antiviral effect of gossypol on chick embryo model].

Authors:  L V Goriunova; S A Vichkanova
Journal:  Farmakol Toksikol       Date:  1969 Sep-Oct

8.  [Antiviral properties of gossypol in experimental influenza pneumonia].

Authors:  S A Vichkanova; A I Oĭfa; L V Goriunova
Journal:  Antibiotiki       Date:  1970-12

Review 9.  Antiviral agents from natural sources.

Authors:  Y Becker
Journal:  Pharmacol Ther       Date:  1980       Impact factor: 12.310

10.  Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin.

Authors:  D Meruelo; G Lavie; D Lavie
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205
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  7 in total

1.  Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

Authors:  R F Schinazi; C K Chu; A Peck; A McMillan; R Mathis; D Cannon; L S Jeong; J W Beach; W B Choi; S Yeola
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

Review 2.  Antiviral therapy for human immunodeficiency virus infections.

Authors:  E De Clercq
Journal:  Clin Microbiol Rev       Date:  1995-04       Impact factor: 26.132

3.  Synthesis of benzyl substituted naphthalenes from benzylidene tetralones.

Authors:  Lorraine M Deck; Quintino Mgani; Andrea Martinez; Alice Martinic; Lisa J Whalen; David L Vander Jagt; Robert E Royer
Journal:  Tetrahedron Lett       Date:  2012-01-25       Impact factor: 2.415

4.  Identification of Novel Natural Products as Effective and Broad-Spectrum Anti-Zika Virus Inhibitors.

Authors:  Yaning Gao; Wanbo Tai; Ning Wang; Xiang Li; Shibo Jiang; Asim K Debnath; Lanying Du; Shizhong Chen
Journal:  Viruses       Date:  2019-11-02       Impact factor: 5.048

Review 5.  Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials.

Authors:  Olga Renner; Mascha Mayer; Christian Leischner; Markus Burkard; Alexander Berger; Ulrich M Lauer; Sascha Venturelli; Stephan C Bischoff
Journal:  Pharmaceuticals (Basel)       Date:  2022-01-26

6.  Traditional Indian medicine and homeopathy for HIV/AIDS: a review of the literature.

Authors:  M Fritts; C C Crawford; D Quibell; A Gupta; W B Jonas; I Coulter; S A Andrade
Journal:  AIDS Res Ther       Date:  2008-12-22       Impact factor: 2.250

7.  Imine-Based Catechols and o-Benzoquinones: Synthesis, Structure, and Features of Redox Behavior.

Authors:  Tatiana V Astaf'eva; Maxim V Arsenyev; Roman V Rumyantcev; Georgy K Fukin; Vladimir K Cherkasov; Andrey I Poddel'sky
Journal:  ACS Omega       Date:  2020-08-21
  7 in total

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