Literature DB >> 26192797

Sigmoidectomy for radiation-induced sigmoid colonic dysplasia 35 years after radiotherapy for cervical cancer.

Kazuaki Uchimoto1, Fumikazu Koyama2, Hisao Fujii3, Tadashi Nakagawa2, Kenichi Ohtsuki2, Shinji Nakamura2, Takeshi Ueda2, Yasunori Enomoto4, Akitaka Nonomura4, Yoshiyuki Nakajima2.   

Abstract

Although radiation-induced colonic cancer is thought to arise from dysplasia, no guidelines exist for the treatment of such dysplasia. Therefore, clinicians must make treatment decisions for this condition on a case-by-case basis. Especially when the operative procedure is being decided, it is necessary to consider postoperative quality of life for advanced age. We report a patient who underwent sigmoidectomy for sigmoid colonic dysplasia that developed 35 years after radiation therapy. A 73-year-old woman who had undergone total hysterectomy and chemoradiotherapy for cervical cancer 35 years previously presented following a positive fecal occult blood test. Colonoscopy revealed sigmoid colonic dysplasia. To ensure reliable removal of the lesion, we elected to perform surgical resection. Given the patient's age, we performed sigmoidectomy rather than resecting the entire irradiated intestinal tract. The diagnosis of dysplasia was confirmed based on pathological findings, which included duct proliferation with partial structural atypia.

Entities:  

Keywords:  Radiation-induced dysplasia; Surgical procedure; Therapeutic strategy

Year:  2009        PMID: 26192797     DOI: 10.1007/s12328-009-0120-x

Source DB:  PubMed          Journal:  Clin J Gastroenterol        ISSN: 1865-7265


  17 in total

1.  Immunohistochemical assessment of Ki67 and p53 expression assists the diagnosis and grading of ulcerative colitis-related dysplasia.

Authors:  N A Wong; N J Mayer; S MacKell; H M Gilmour; D J Harrison
Journal:  Histopathology       Date:  2000-08       Impact factor: 5.087

Review 2.  Radiation-induced sequelae affecting the continence organ: incidence, pathogenesis, and treatment.

Authors:  Sven Petersen; Johannes Jongen; Cordula Petersen; Marco Sailer
Journal:  Dis Colon Rectum       Date:  2007-09       Impact factor: 4.585

3.  Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

Authors:  T A Brentnall; D A Crispin; P S Rabinovitch; R C Haggitt; C E Rubin; A C Stevens; G C Burmer
Journal:  Gastroenterology       Date:  1994-08       Impact factor: 22.682

4.  Radiation-associated rectal cancer: report of four cases.

Authors:  O Tamai; E Nozato; H Miyazato; T Isa; S Hiroyasu; M Shiraishi; T Kusano; Y Muto; M Higashi
Journal:  Dig Surg       Date:  1999       Impact factor: 2.588

5.  Colorectal cancer after pelvic irradiation: case reports.

Authors:  A Tsunoda; M Shibusawa; M Kawamura; T Marumori; M Kusano; H Ohta
Journal:  Anticancer Res       Date:  1997 Jan-Feb       Impact factor: 2.480

6.  Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis.

Authors:  K Holzmann; B Klump; F Borchard; C J Hsieh; A Kühn; V Gaco; M Gregor; R Porschen
Journal:  Int J Cancer       Date:  1998-03-30       Impact factor: 7.396

7.  Radiation-induced rectal cancer originating from a rectocutaneous fistula: report of a case.

Authors:  Shozo Yokoyama; Katsunari Takifuji; Kazuo Arii; Hajime Tanaka; Kenji Matsuda; Takashi Higashiguchi; Hiroki Yamaue
Journal:  Surg Today       Date:  2004       Impact factor: 2.549

8.  Clinicopathologic characteristics of large bowel cancer developing after radiotherapy for uterine cervical cancer.

Authors:  K Shirouzu; H Isomoto; T Morodomi; Y Ogata; Y Araki; T Kakegawa
Journal:  Dis Colon Rectum       Date:  1994-12       Impact factor: 4.585

9.  Immunohistochemical study of p53 overexpression in radiation-induced colon cancers.

Authors:  K Minami; S Matsuzaki; N Hayashi; A Mokarim; M Ito; I Sekine
Journal:  J Radiat Res       Date:  1998-03       Impact factor: 2.724

Review 10.  Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy.

Authors:  C McGough; C Baldwin; G Frost; H J N Andreyev
Journal:  Br J Cancer       Date:  2004-06-14       Impact factor: 7.640

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.