| Literature DB >> 26192797 |
Kazuaki Uchimoto1, Fumikazu Koyama2, Hisao Fujii3, Tadashi Nakagawa2, Kenichi Ohtsuki2, Shinji Nakamura2, Takeshi Ueda2, Yasunori Enomoto4, Akitaka Nonomura4, Yoshiyuki Nakajima2.
Abstract
Although radiation-induced colonic cancer is thought to arise from dysplasia, no guidelines exist for the treatment of such dysplasia. Therefore, clinicians must make treatment decisions for this condition on a case-by-case basis. Especially when the operative procedure is being decided, it is necessary to consider postoperative quality of life for advanced age. We report a patient who underwent sigmoidectomy for sigmoid colonic dysplasia that developed 35 years after radiation therapy. A 73-year-old woman who had undergone total hysterectomy and chemoradiotherapy for cervical cancer 35 years previously presented following a positive fecal occult blood test. Colonoscopy revealed sigmoid colonic dysplasia. To ensure reliable removal of the lesion, we elected to perform surgical resection. Given the patient's age, we performed sigmoidectomy rather than resecting the entire irradiated intestinal tract. The diagnosis of dysplasia was confirmed based on pathological findings, which included duct proliferation with partial structural atypia.Entities:
Keywords: Radiation-induced dysplasia; Surgical procedure; Therapeutic strategy
Year: 2009 PMID: 26192797 DOI: 10.1007/s12328-009-0120-x
Source DB: PubMed Journal: Clin J Gastroenterol ISSN: 1865-7265