PURPOSE: To assess outcomes of lung nodules missed on simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) compared to the reference standard PET and computed tomography (PET/CT) in patients with primary malignancy. MATERIALS AND METHODS: In all, 208 patients with primary malignancy undergoing clinically indicated (18F) fluorodeoxyglucose (FDG) PET/CT followed by PET/MRI were independently reviewed by two readers. Upon review of the thoracic station on PET/MRI and PET/CT, 89 non-FDG avid small lung nodules in 43 patients were detected (by reader 1) only on the CT component of the PET/CT but were not identified on PET/MRI. Overall, 84 of these 89 nodules were examined on follow-up imaging with PET/CT or chest CT. The remaining five nodules had no follow-up imaging but had remote imaging available for comparison. RESULTS: Among the 84 nodules with follow-up, three nodules (3%) in one patient progressed, 10 (12%) nodules partially/completely resolved, whereas 71 nodules (85%) remained stable. The five nodules without follow-up were all stable since prior imaging of over 21 months. CONCLUSION: The vast majority (97%) of small non-FDG avid lung nodules missed on PET/MRI either resolved or remained stable on follow-up, suggestive of benignity. PET/MRI remains a viable alternative imaging modality in oncology patients, despite its low sensitivity in detecting small lung nodules.
PURPOSE: To assess outcomes of lung nodules missed on simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) compared to the reference standard PET and computed tomography (PET/CT) in patients with primary malignancy. MATERIALS AND METHODS: In all, 208 patients with primary malignancy undergoing clinically indicated (18F) fluorodeoxyglucose (FDG) PET/CT followed by PET/MRI were independently reviewed by two readers. Upon review of the thoracic station on PET/MRI and PET/CT, 89 non-FDG avid small lung nodules in 43 patients were detected (by reader 1) only on the CT component of the PET/CT but were not identified on PET/MRI. Overall, 84 of these 89 nodules were examined on follow-up imaging with PET/CT or chest CT. The remaining five nodules had no follow-up imaging but had remote imaging available for comparison. RESULTS: Among the 84 nodules with follow-up, three nodules (3%) in one patient progressed, 10 (12%) nodules partially/completely resolved, whereas 71 nodules (85%) remained stable. The five nodules without follow-up were all stable since prior imaging of over 21 months. CONCLUSION: The vast majority (97%) of small non-FDG avid lung nodules missed on PET/MRI either resolved or remained stable on follow-up, suggestive of benignity. PET/MRI remains a viable alternative imaging modality in oncology patients, despite its low sensitivity in detecting small lung nodules.
Authors: Pierpaolo Biondetti; Mark G Vangel; Rita M Lahoud; Felipe S Furtado; Bruce R Rosen; David Groshar; Lina G Canamaque; Lale Umutlu; Eric W Zhang; Umar Mahmood; Subba R Digumarthy; Jo-Anne O Shepard; Onofrio A Catalano Journal: Eur J Nucl Med Mol Imaging Date: 2021-01-07 Impact factor: 9.236
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Authors: Benedikt M Schaarschmidt; Johannes Grueneisen; Martin Metzenmacher; Benedikt Gomez; Thomas Gauler; Christian Roesel; Philipp Heusch; Verena Ruhlmann; Lale Umutlu; Gerald Antoch; Christian Buchbender Journal: Eur Radiol Date: 2016-05-14 Impact factor: 5.315
Authors: Amy N Melsaether; Roy A Raad; Akshat C Pujara; Fabio D Ponzo; Kristine M Pysarenko; Komal Jhaveri; James S Babb; Eric E Sigmund; Sungheon G Kim; Linda A Moy Journal: Radiology Date: 2016-03-29 Impact factor: 11.105
Authors: Nina F Schwenzer; Ferdinand Seith; Sergios Gatidis; Cornelia Brendle; Holger Schmidt; Christina A Pfannenberg; Christian laFougère; Konstantin Nikolaou; Christina Schraml Journal: Korean J Radiol Date: 2016-08-23 Impact factor: 3.500