| Literature DB >> 26192628 |
Hanady Ajine Bibi1, Massimiliano di Cagno2, Rene Holm3, Annette Bauer-Brandl4.
Abstract
The aim of the present work was to investigate the potential of the new and innovative artificial barrier, Permeapad™, when exposed to surfactants and co-solvents, often employed for poorly water soluble compounds. The barrier was in addition also exposed to fasted and fed state simulated intestinal fluids versions 1 and 2 (FaSSIF and FeSSIF), all of which the Permeapad™ barrier was compatible with based upon relative comparison of the permeability of the hydrophilic marker calcein in phosphate buffer. The new barrier therefore holds a huge potential due to its functional stability and robustness. It can be used as a standard tool to investigate permeability of drugs in the presence of different surfactants and co-solvents, from DMSO stock solutions at even high concentrations and for the evaluation of permeability in the presence of biomimetic media (BMM).Entities:
Keywords: Apparent permeability; Caffeine (PubChem CID: 2519); Calcein (PubChem CID: 65079); Co-solvents; Dimethylsulphoxide (DMSO) (PubChem CID: 679); FaSSIF; FeSSIF; MacrogolG R (PubChem CID: 81307); Permeapad™; Polysorbate 80 (PubChem CID: 5284448); Sodiumdocecylsulphate (SDS) (PubChem CID: 8778); Surfactants; Triton-X (PubChem CID: 5590)
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Year: 2015 PMID： 26192628 DOI： 10.1016/j.ijpharm.2015.07.028
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875