Jian Luo1, Ling-Peng Wang2, Hai-Feng Hu3, Li Zhang1, Ya-Li Li1, Li-Man Ai2, Hu-Yati Mu4. 1. Department of Cardiology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China. 2. Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China. 3. Department of Heart and Renal of The Sixth People's Hospital in Xinjiang Uygur Autonomous Region, Urumqi 830000, China. 4. Department of Internal Medicine (VIP) of The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China. Electronic address: muyatihuxj@163.com.
Abstract
BACKGROUND: Elevated cystatin C level was associated with excessive risk of cardiovascular events and mortality in the highly cardiovascular risk populations. We conducted this meta-analysis to investigate the relationship between serum cystatin C level and cardiovascular or all-cause mortality risk in the general population. METHODS: We searched for all relevant studies published through May 2015 using PubMed, Embase, and Cochrane Library. Prospective studies that assessed the relationship between serum cystatin C level and cardiovascular or all-cause mortality risk in the general population were selected. Pooled adjust hazard risk (HR) and the corresponding 95% confidence intervals (CI) were calculated for continuous and category of cystatin C level. RESULTS: Nine studies composed of 38,854 participants were analyzed. Elevated serum cystatin C level was associated with excessive risk of all-cause mortality (HR 1.72; 95% CI 1.37-2.16) and cardiovascular mortality (HR 2.74; 95% CI 2.04-3.68) comparing the highest to lowest category of cystatin C. Each standard deviation increment in serum cystatin C level increased 32% all-cause (HR 1.32; 95% CI 1.12-1.55) and 57% cardiovascular mortality (HR 1.57; 95% CI 1.31-1.88) risk. CONCLUSIONS: Elevated serum cystatin C level is independently associated with excessive cardiovascular and all-cause mortality risk in elderly persons.
BACKGROUND: Elevated cystatin C level was associated with excessive risk of cardiovascular events and mortality in the highly cardiovascular risk populations. We conducted this meta-analysis to investigate the relationship between serum cystatin C level and cardiovascular or all-cause mortality risk in the general population. METHODS: We searched for all relevant studies published through May 2015 using PubMed, Embase, and Cochrane Library. Prospective studies that assessed the relationship between serum cystatin C level and cardiovascular or all-cause mortality risk in the general population were selected. Pooled adjust hazard risk (HR) and the corresponding 95% confidence intervals (CI) were calculated for continuous and category of cystatin C level. RESULTS: Nine studies composed of 38,854 participants were analyzed. Elevated serum cystatin C level was associated with excessive risk of all-cause mortality (HR 1.72; 95% CI 1.37-2.16) and cardiovascular mortality (HR 2.74; 95% CI 2.04-3.68) comparing the highest to lowest category of cystatin C. Each standard deviation increment in serum cystatin C level increased 32% all-cause (HR 1.32; 95% CI 1.12-1.55) and 57% cardiovascular mortality (HR 1.57; 95% CI 1.31-1.88) risk. CONCLUSIONS: Elevated serum cystatin C level is independently associated with excessive cardiovascular and all-cause mortality risk in elderly persons.
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