| Literature DB >> 26191271 |
Kun He1, Zemin Hu2, Jiahou Ruan2, Qianhong Ma2, Feng Zhong3, Xinsheng Cheng3, Shibo Sun3, Jie Zhou3.
Abstract
We explored microRNA301 diagnosis value in hepatocellular cancer (HCC), attempting to provide novel insights for early detection, effective prevention, and timely treatment. 42 patients with HCC and 38 controls composed of 9 liver cirrhosis (LC), 9 chronic hepatitis B (CHB) and 20 healthy individuals were investigated in the study. Serum microRNA301 expression levels were detected using fluorescent quantitative polymerase chain reaction (FQ-PCR) technology. ROC curve was performed to evaluate diagnosis value of microRNA301. Meanwhile, the correlations of microRNA301 levels with clinical characteristics were also analyzed. Significantly up-regulated expression of serum microRNA301 was seen in HCC patients compared with the controls (P<0.05). We also noted that level changes of microRNA301 were associated with differentiation, alpha fetoprotein (AFP), portal vein-emboli and HasAg (P<0.05), rather than age, gender and tumor size. Based on the area under ROC curve of 0.880, the critical value of microRNA301 was 2.3530 and the sensitivity and specificity were 88.1% and 70.3%, respectively. The results of this study revealed that microRNA301 might function as a potential diagnostic biomarker for HCC.Entities:
Keywords: Hepatocellular cancer; MicroRNA301; diagnosis
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Year: 2015 PMID： 26191271 PMCID： PMC4503142
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625