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Literature DB >> 2619041

Glutathione monoesters.

Abstract

Glutathione monoesters in which the glycine carboxyl group is esterified are effective cellular glutathione delivery agents because they are readily transported into cells and are deesterified intracellularly. In contrast, glutathione itself is not effectively transported into cells. Detailed procedures are given for the preparation of such esters from glutathione and the corresponding alcohol using hydrogen chloride or sulfuric acid as the catalyst.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2619041 DOI： 10.1016/0003-2697(89)90164-4

Source DB: PubMed Journal: Anal Biochem ISSN： 0003-2697 Impact factor: 3.365

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Cited

27 in total

1. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

Authors: J Mårtensson; R Steinherz; A Jain; A Meister
Journal: Proc Natl Acad Sci U S A Date: 1989-11 Impact factor: 11.205

2. Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle.

Authors: A Jain; J Mårtensson; T Mehta; A N Krauss; P A Auld; A Meister
Journal: Proc Natl Acad Sci U S A Date: 1992-06-01 Impact factor: 11.205

Glutathione monoesters.

1. Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage.

2. Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle.

3. Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects.

4. High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function.

5. Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

6. Glutathione deficiency leads to mitochondrial damage in brain.

7. Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients.

8. Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats.

9. Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs.

10. Transport of glutathione diethyl ester into human cells.