Literature DB >> 26189999

Achalasia, chronic sensory neuropathy, and N-type calcium channel autoantibodies: beneficial response to IVIG.

Hugh J McMillan1, Jayashri Srinivasan2.   

Abstract

Autoimmune gastrointestinal dysmotility (AGID) can result from paraneoplastic onconeuronal antibodies. Patients may present with regional hypomotility anywhere along the gastrointestinal tract. We report a case of a woman who developed an insidious sensory neuropathy and achalasia. She was found to have a high-titer of N-type voltage gated-calcium channel (VGCC) antibodies. She demonstrated clinical and electrophysiological improvement of her neuropathy, as well as improvement of her swallowing and gait, after treatment with intravenous immunoglobulins.

Entities:  

Keywords:  Autoantibodies; Esophageal achalasia; Gait ataxia; Intravenous immunoglobulins; N-type calcium channel; Paraneoplastic syndromes

Year:  2010        PMID： 26189999     DOI： 10.1007/s12328-010-0140-6

Source DB:  PubMed          Journal:  Clin J Gastroenterol        ISSN： 1865-7265


  23 in total

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2.  Benefit of IVIg for long-standing ataxic sensory neuronopathy with Sjögren's syndrome.

Authors:  Gil I Wolfe; Sharon P Nations; Dennis K Burns; Laura L Herbelin; Richard J Barohn
Journal:  Neurology       Date:  2003-09-23       Impact factor: 9.910

Review 3.  Voltage-gated calcium channels in autonomic neuroeffector transmission.

Authors:  S A Waterman
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4.  Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies.

Authors:  S Vernino; P A Low; R D Fealey; J D Stewart; G Farrugia; V A Lennon
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5.  Paraneoplastic gastrointestinal motor dysfunction: clinical and laboratory characteristics.

Authors:  H R Lee; V A Lennon; M Camilleri; C M Prather
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6.  Neurologic improvement after high-dose intravenous immunoglobulin therapy in patients with paraneoplastic cerebellar degeneration associated with anti-Purkinje cell antibody.

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Authors:  F Keime-Guibert; F Graus; A Fleury; R René; J Honnorat; P Broet; J Y Delattre
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Authors:  R H Holloway; W J Dodds; J F Helm; W J Hogan; J Dent; R C Arndorfer
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3.  Autoimmune Gastrointestinal Dysmotility in a Patient With HIV Treated With Methylprednisolone and Pyridostigmine.

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5.  Clinical Improvement With Pyridostigmine in a Patient With Acetylcholine Receptor Antibody-Associated Autoimmune Gastrointestinal Dysmotility.

Authors:  Shaina Sekhri; Benson Massey; Poonam Beniwal-Patel
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  5 in total

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