Katja Linda Waller1, Erik Lykke Mortensen2, Kirsten Avlund2, Merete Osler3, Birgitte Fagerlund4, Martin Lauritzen5, Poul Jennum6. 1. Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup Hospital, Glostrup, Copenhagen, Denmark; Faculty of Health Science, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. Electronic address: katja.linda.waller.01@regionh.dk. 2. Faculty of Health Science, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 3. Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Research Center for Prevention and Health, Glostrup Hospital, Glostrup, Copenhagen, Denmark. 4. Center for Neuropsychiatric Schizophrenia Research and Lundbeck Foundation Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research, University of Copenhagen, Psychiatric Centre Glostrup, Glostrup, Copenhagen, Denmark. 5. Faculty of Health Science, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Neurophysiology, Glostrup Hospital, Glostrup, Copenhagen, Denmark. 6. Department of Clinical Neurophysiology, Danish Center for Sleep Medicine, Glostrup Hospital, Glostrup, Copenhagen, Denmark; Faculty of Health Science, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Abstract
UNLABELLED: In an increasingly aged population, sleep disturbances and neurodegenerative disorders have become a major public health concern. Poor sleep quality and cognitive changes are complex health problems in aging populations that are likely to be associated with increased frailty, morbidity, and mortality, and to be potential risk factors for further cognitive impairment. We aimed to evaluate whether sleep quality and excessive daytime sleepiness may be considered as early predictors of cognitive impairment. STUDY OBJECTIVES: The objective of this study was to examine whether subjective sleep quality and daytime sleepiness are associated with cognition in middle-aged males. PARTICIPANTS: A total of 189 healthy males born in 1953 were considered as participants for the study. Based on previous cognitive assessments, the participants were selected for the study as cognitively improved (N = 97) or cognitively impaired (N = 92). METHODS: The Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale measured subjective sleep quality and daytime sleepiness, respectively. Depressive symptoms were determined using Beck's Depression Inventory (BDI-II). A neuropsychological battery was administered to confirm group differences in cognitive functioning at the time when sleep data were collected. RESULTS: Compared with cognitively improved males, the cognitively impaired group reported significantly lower subjective sleep quality (5.40 ± 3.81 vs. 4.39 ± 2.40, p = 0.03). Forty-one percent of the sample exhibited poor sleep quality and 15% experienced excessive daytime sleepiness. There were few correlations between sleep parameters and cognitive test performance in the combined sample. CONCLUSION: Self-reported poor sleep quality was related to cognitive changes, whereas daytime sleepiness was not related. Our results suggest that sleep quality may be an early marker of cognitive decline in midlife.
UNLABELLED: In an increasingly aged population, sleep disturbances and neurodegenerative disorders have become a major public health concern. Poor sleep quality and cognitive changes are complex health problems in aging populations that are likely to be associated with increased frailty, morbidity, and mortality, and to be potential risk factors for further cognitive impairment. We aimed to evaluate whether sleep quality and excessive daytime sleepiness may be considered as early predictors of cognitive impairment. STUDY OBJECTIVES: The objective of this study was to examine whether subjective sleep quality and daytime sleepiness are associated with cognition in middle-aged males. PARTICIPANTS: A total of 189 healthy males born in 1953 were considered as participants for the study. Based on previous cognitive assessments, the participants were selected for the study as cognitively improved (N = 97) or cognitively impaired (N = 92). METHODS: The Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale measured subjective sleep quality and daytime sleepiness, respectively. Depressive symptoms were determined using Beck's Depression Inventory (BDI-II). A neuropsychological battery was administered to confirm group differences in cognitive functioning at the time when sleep data were collected. RESULTS: Compared with cognitively improved males, the cognitively impaired group reported significantly lower subjective sleep quality (5.40 ± 3.81 vs. 4.39 ± 2.40, p = 0.03). Forty-one percent of the sample exhibited poor sleep quality and 15% experienced excessive daytime sleepiness. There were few correlations between sleep parameters and cognitive test performance in the combined sample. CONCLUSION: Self-reported poor sleep quality was related to cognitive changes, whereas daytime sleepiness was not related. Our results suggest that sleep quality may be an early marker of cognitive decline in midlife.
Authors: Diego Z Carvalho; Erik K St Louis; Bradley F Boeve; Michelle M Mielke; Scott A Przybelski; David S Knopman; Mary M Machulda; Rosebud O Roberts; Yonas E Geda; Ronald C Petersen; Clifford R Jack; Prashanthi Vemuri Journal: Sleep Med Date: 2016-11-03 Impact factor: 3.492
Authors: Markus Waser; Martin J Lauritzen; Birgitte Fagerlund; Merete Osler; Erik L Mortensen; Helge B D Sørensen; Poul Jennum Journal: J Sleep Res Date: 2018-11-12 Impact factor: 3.981
Authors: Lena L Law; Kate E Sprecher; Ryan J Dougherty; Dorothy F Edwards; Rebecca L Koscik; Catherine L Gallagher; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Sanjay Asthana; Mark A Sager; Bruce P Hermann; Sterling C Johnson; Dane B Cook; Barbara B Bendlin; Ozioma C Okonkwo Journal: J Alzheimers Dis Date: 2019 Impact factor: 4.472
Authors: Christiane E Sørensen; Naja L Hansen; Erik L Mortensen; Martin Lauritzen; Merete Osler; Anne M L Pedersen Journal: Front Aging Neurosci Date: 2018-01-30 Impact factor: 5.750