| Literature DB >> 26188281 |
Mark H Mannino1, Ziwen Zhu1, Huaping Xiao2, Qian Bai1, Mark R Wakefield1, Yujiang Fang3.
Abstract
Interleukin-10 (IL-10) produced by a wide-variety of cells is a highly pleiotropic cytokine. It has been implicated in the pathogenesis and/or development of autoimmune diseases and cancer, although it displays differential effects that seem to be contradictory sometimes. The ultimate role of this cytokine in disease, however, cannot be fully determined until the immunological contexts that regulate its function are further elucidated. In this review, we will discuss a wide variety of evidence of IL-10 in immunity and cancer in an effort to illuminate the remaining mysteries in the function of this cytokine that, when fully understood, may prove to be a powerful tool in the battle against cancer.Entities:
Keywords: Cancer; IL-10; Immune
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Year: 2015 PMID： 26188281 DOI： 10.1016/j.canlet.2015.07.009
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679