Literature DB >> 26188072

IL-17-Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans.

Heather R Conti1, Sarah L Gaffen2.   

Abstract

IL-17 (IL-17A) has emerged as a key mediator of protection against extracellular microbes, but this cytokine also drives pathology in various autoimmune diseases. Overwhelming data in both humans and mice reveal a clear and surprisingly specific role for IL-17 in protection against the fungus Candida albicans, a commensal microbe of the human oral cavity, gastrointestinal tract, and reproductive mucosa. The IL-17 pathway regulates antifungal immunity through upregulation of proinflammatory cytokines, including IL-6, neutrophil-recruiting chemokines (e.g., CXCL1 and CXCL5), and antimicrobial peptides (e.g., defensins), which act in concert to limit fungal overgrowth. This review focuses on diseases caused by C. albicans, the role of IL-17-mediated immunity in candidiasis, and the implications for clinical therapies for both autoimmune conditions and fungal infections.
Copyright © 2015 by The American Association of Immunologists, Inc.

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Year:  2015        PMID： 26188072      PMCID： PMC4507294          DOI： 10.4049/jimmunol.1500909

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  123 in total

Review 1.  Th17 cells in immunity to Candida albicans.

Authors:  Nydiaris Hernández-Santos; Sarah L Gaffen
Journal:  Cell Host Microbe       Date:  2012-05-17       Impact factor: 21.023

Review 2.  Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.

Authors:  Junko Yano; Mairi C Noverr; Paul L Fidel
Journal:  Cytokine       Date:  2011-12-17       Impact factor: 3.861

3.  Neutrophils produce interleukin 17A (IL-17A) in a dectin-1- and IL-23-dependent manner during invasive fungal infection.

Authors:  Jessica L Werner; Melissa A Gessner; Lauren M Lilly; Michael P Nelson; Allison E Metz; Dawn Horn; Chad W Dunaway; Jessy Deshane; David D Chaplin; Casey T Weaver; Gordon D Brown; Chad Steele
Journal:  Infect Immun       Date:  2011-08-01       Impact factor: 3.441

4.  Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism.

Authors:  Tomohiro Hori; Hidenori Ohnishi; Takahide Teramoto; Kohji Tsubouchi; Takafumi Naiki; Yoshinobu Hirose; Osamu Ohara; Mariko Seishima; Hideo Kaneko; Toshiyuki Fukao; Naomi Kondo
Journal:  J Clin Immunol       Date:  2012-07-31       Impact factor: 8.317

5.  IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.

Authors:  Hye-Lin Ha; Hongshan Wang; Prapaporn Pisitkun; Jin-Chul Kim; Ilaria Tassi; Wanhu Tang; Maria I Morasso; Mark C Udey; Ulrich Siebenlist
Journal:  Proc Natl Acad Sci U S A       Date:  2014-08-04       Impact factor: 11.205

6.  Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells.

Authors:  Eva V Acosta-Rodriguez; Laura Rivino; Jens Geginat; David Jarrossay; Marco Gattorno; Antonio Lanzavecchia; Federica Sallusto; Giorgio Napolitani
Journal:  Nat Immunol       Date:  2007-05-07       Impact factor: 25.606

7.  Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils.

Authors:  Patricia R Taylor; Sixto M Leal; Yan Sun; Eric Pearlman
Journal:  J Immunol       Date:  2014-03-03       Impact factor: 5.422

Review 8.  C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.

Authors:  Anthony Plato; Janet A Willment; Gordon D Brown
Journal:  Int Rev Immunol       Date:  2013-04       Impact factor: 5.311

9.  Fungi of the murine gut: episodic variation and proliferation during antibiotic treatment.

Authors:  Serena Dollive; Ying-Yu Chen; Stephanie Grunberg; Kyle Bittinger; Christian Hoffmann; Lee Vandivier; Christopher Cuff; James D Lewis; Gary D Wu; Frederic D Bushman
Journal:  PLoS One       Date:  2013-08-19       Impact factor: 3.240

10.  Rheumatoid arthritis patients exhibit impaired Candida albicans-specific Th17 responses.

Authors:  Shrinivas Bishu; Ee Wern Su; Erich R Wilkerson; Kelly A Reckley; Donald M Jones; Mandy J McGeachy; Sarah L Gaffen; Marc C Levesque
Journal:  Arthritis Res Ther       Date:  2014-02-11       Impact factor: 5.156
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  102 in total

1.  CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE.

Authors:  Michelle R Simpson-Abelson; Gerard Hernandez-Mir; Erin E Childs; J Agustin Cruz; Amanda C Poholek; Ansuman Chattopadhyay; Sarah L Gaffen; Mandy J McGeachy
Journal:  Cytokine       Date:  2017-01-12       Impact factor: 3.861

2.  IL-17 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.

Authors:  Rao Me; Nan Gao; Chenyang Dai; Fu-Shin X Yu
Journal:  J Immunol       Date:  2019-11-25       Impact factor: 5.422

3.  Candida albicans Elicits Pro-Inflammatory Differential Gene Expression in Intestinal Peyer's Patches.

Authors:  Navjot Singh; Heather C Kim; Renjie Song; Jaskiran K Dhinsa; Steven R Torres; Magdia De Jesus
Journal:  Mycopathologia       Date:  2019-06-22       Impact factor: 2.574

4.  Interleukin-17 mediated immunity during infections with Trypanosoma cruzi and other protozoans.

Authors:  María Carolina Amezcua Vesely; Constanza Rodríguez; Adriana Gruppi; Eva Virginia Acosta Rodríguez
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-01-24       Impact factor: 5.187

5.  IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.

Authors:  Lu Sun; Mustafa Girnary; Lufei Wang; Yizu Jiao; Erliang Zeng; Kyle Mercer; Jinmei Zhang; Julie T Marchesan; Ning Yu; Kevin Moss; Yu L Lei; Steven Offenbacher; Shaoping Zhang
Journal:  J Immunol       Date:  2020-03-13       Impact factor: 5.422

6.  Novel Role for Interleukin-17 in Enhancing Type 1 Helper T Cell Immunity in the Female Genital Tract following Mucosal Herpes Simplex Virus 2 Vaccination.

Authors:  Puja Bagri; Varun C Anipindi; Philip V Nguyen; Danielle Vitali; Martin R Stämpfli; Charu Kaushic
Journal:  J Virol       Date:  2017-11-14       Impact factor: 5.103

7.  Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

Authors:  Fang Shen; Akash H Verma; Amy Volk; Brian Jones; Bianca M Coleman; Matthew J Loza; Ravi Malaviya; Beverley Moore; Daniel Weinstock; M Merle Elloso; Sarah L Gaffen; Tatiana Ort
Journal:  J Immunol       Date:  2019-02-11       Impact factor: 5.422

Review 8.  Mining the oral mycobiome: Methods, components, and meaning.

Authors:  Patricia I Diaz; Bo-Young Hong; Amanda K Dupuy; Linda D Strausbaugh
Journal:  Virulence       Date:  2016-10-28       Impact factor: 5.882

9.  Fungus Among Us: The Frenemies Within.

Authors:  Felix E Y Aggor; Sing Sing Way; Sarah L Gaffen
Journal:  Trends Immunol       Date:  2019-04-30       Impact factor: 16.687

10.  Pulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis.

Authors:  Chiara Ripamonti; Lisa R Bishop; Joseph A Kovacs
Journal:  Infect Immun       Date:  2017-06-20       Impact factor: 3.441
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