Literature DB >> 26187649

Transient effects of levamisole on Brugia malayi microfilariae.

Eman Mostafa1, Bob Storey, Adel Mohammed Farghaly, Hany Abd El-Hai Afify, Afaf Abd El-Raouf Taha, Adrian J Wolstenholme.   

Abstract

Levamisole is an anthelmintic drug that acts by activating nicotinic acetylcholine receptors at the nematode neuromuscular junction and causing paralysis. We measured the in vitro effects of levamisole on the motility of Brugia malayi microfilariae; after 2 h incubation the apparent IC50 was 2.68 mM. Lower drug concentrations, such as 1 mM, caused an immediate total paralysis that lasted for up to 1 h, but was completely reversed by 2 h of incubation. The 'recovered' parasites were still completely susceptible to application of a second nicotinic agonist, pyrantel.

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Year:  2015        PMID： 26187649     DOI： 10.1007/s10158-015-0181-0

Source DB:  PubMed          Journal:  Invert Neurosci        ISSN： 1354-2516


  15 in total

1.  Agonists cause endocytosis of nicotinic acetylcholine receptors on cultured myotubes.

Authors:  P A St John; H Gordon
Journal:  J Neurobiol       Date:  2001-11-15

2.  Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum.

Authors:  Hai Qian; Richard J Martin; Alan P Robertson
Journal:  FASEB J       Date:  2006-10-20       Impact factor: 5.191

Review 3.  Experimental chemotherapy of filariasis: comparative evaluation of the efficacy of filaricidal compounds in Mastomys coucha infected with Litomosoides carinii, Acanthocheilonema viteae, Brugia malayi and B. pahangi.

Authors:  H Zahner; G Schares
Journal:  Acta Trop       Date:  1993-01       Impact factor: 3.112

4.  Single-channel recording from adult Brugia malayi.

Authors:  Alan P Robertson; Sreekanth Puttachary; Richard J Martin
Journal:  Invert Neurosci       Date:  2011-05-18

Review 5.  Modes of action of anthelmintic drugs.

Authors:  R J Martin
Journal:  Vet J       Date:  1997-07       Impact factor: 2.688

6.  The cys-loop ligand-gated ion channel gene family of Brugia malayi and Trichinella spiralis: a comparison with Caenorhabditis elegans.

Authors:  Sally M Williamson; Thomas K Walsh; Adrian J Wolstenholme
Journal:  Invert Neurosci       Date:  2007-10-20

7.  Whole-cell patch-clamp recording of nicotinic acetylcholine receptors in adult Brugia malayi muscle.

Authors:  A P Robertson; S K Buxton; R J Martin
Journal:  Parasitol Int       Date:  2013-04-03       Impact factor: 2.230

8.  Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms.

Authors:  Ben-Wen Li; Amy C Rush; Gary J Weil
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-06-23       Impact factor: 4.077

9.  The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits.

Authors:  Sally M Williamson; Alan P Robertson; Laurence Brown; Tracey Williams; Debra J Woods; Richard J Martin; David B Sattelle; Adrian J Wolstenholme
Journal:  PLoS Pathog       Date:  2009-07-17       Impact factor: 6.823

Review 10.  Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans.

Authors:  Andrew K Jones; David B Sattelle
Journal:  Bioessays       Date:  2004-01       Impact factor: 4.345
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  4 in total

Review 1.  High-content approaches to anthelmintic drug screening.

Authors:  Mostafa Zamanian; John D Chan
Journal:  Trends Parasitol       Date:  2021-06-03

2.  The genome of Onchocerca volvulus, agent of river blindness.

Authors:  James A Cotton; Sasisekhar Bennuru; Alexandra Grote; Bhavana Harsha; Alan Tracey; Robin Beech; Stephen R Doyle; Matthew Dunn; Julie C Dunning Hotopp; Nancy Holroyd; Taisei Kikuchi; Olivia Lambert; Amruta Mhashilkar; Prudence Mutowo; Nirvana Nursimulu; Jose M C Ribeiro; Matthew B Rogers; Eleanor Stanley; Lakshmipuram S Swapna; Isheng J Tsai; Thomas R Unnasch; Denis Voronin; John Parkinson; Thomas B Nutman; Elodie Ghedin; Matthew Berriman; Sara Lustigman
Journal:  Nat Microbiol       Date:  2016-11-21       Impact factor: 17.745

3.  Ivermectin inhibits extracellular vesicle secretion from parasitic nematodes.

Authors:  Hannah J Loghry; Wang Yuan; Mostafa Zamanian; Nicolas J Wheeler; Timothy A Day; Michael J Kimber
Journal:  J Extracell Vesicles       Date:  2020-12-10

4.  Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.

Authors:  Alexandra Blanchard; Fabrice Guégnard; Claude L Charvet; Anna Crisford; Elise Courtot; Christine Sauvé; Abdallah Harmache; Thomas Duguet; Vincent O'Connor; Philippe Castagnone-Sereno; Barbara Reaves; Adrian J Wolstenholme; Robin N Beech; Lindy Holden-Dye; Cedric Neveu
Journal:  PLoS Pathog       Date:  2018-05-02       Impact factor: 6.823
  4 in total

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