S Trattnig1, K Ohel2, V Mlynarik3, V Juras4, S Zbyn5, A Korner6. 1. High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria; CD Laboratory for Clinical Molecular MR Imaging, Austria. Electronic address: siegfried.trattnig@meduniwien.ac.at. 2. Regentis Biomaterials Ltd., 12 Ha'ilan Street, Northern Industrial Zone, P.O.B. 260, Or Akiva, 3060000, Israel. Electronic address: Kitty@regentis.co.il. 3. High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria. Electronic address: vladimir.mlynarik@meduniwien.ac.at. 4. High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria. Electronic address: vladimir.juras@meduniwien.ac.at. 5. High Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria. Electronic address: stefan.zbyn@meduniwien.ac.at. 6. Regentis Biomaterials Ltd., 12 Ha'ilan Street, Northern Industrial Zone, P.O.B. 260, Or Akiva, 3060000, Israel. Electronic address: Amit@regentis.co.il.
Abstract
OBJECTIVE: To evaluate cartilage repair tissue (RT) using MOCART scoring for morphological and T2 mapping for biochemical assessment following implantation of GelrinC, a biosynthetic, biodegradable hydrogel implant. DESIGN: MR imaging (1.5/3T) was performed on 21 patients at six sites. Standard protocols were used for MOCART evaluation at 1 week (baseline) 1, 3, 6, 12, 18 and 24 months. Multi-echo SE was used for T2 mapping. Global (T2 in RT divided by T2 in normal cartilage) and zonal T2 index (deep T2 divided by superficial T2) of RT were calculated. RESULTS: Average MOCART score was 71.8 (95% CI 62.2 to 81.3) at six, 75.2 (95% CI 62.8 to 87.5) at twelve, 71.8 (95% CI 55.4 to 88.2) at eighteen and 84.4 (95% CI 77.7 to 91.0) at twenty-four months. The global T2 index ranged between 0.8 and 1.2 (normal healthy cartilage) in 1/11 (9%) patients at baseline, 8/12 (67%) at 12 months, 11/13 (85%) at 18 months and 13/16 (81%) at 24 months. The zonal T2 index for RT was <20% difference to the zonal T2 index for normal cartilage in: 6/12 patients (50%) at 12 months, 7/13 (53.8%) at 18 months and 10/16 (63.5%) at 24 months. The standard deviation for T2 showed a significant decrease over the study. CONCLUSIONS: The increase of MOCART scores over follow-up indicates improving cartilage repair tissue. Global and zonal T2 repair values at 24 months reached normal cartilage in 81% and 63.5% of the patients respectively, reflecting collagen organization similar to hyaline cartilage.
OBJECTIVE: To evaluate cartilage repair tissue (RT) using MOCART scoring for morphological and T2 mapping for biochemical assessment following implantation of GelrinC, a biosynthetic, biodegradable hydrogel implant. DESIGN: MR imaging (1.5/3T) was performed on 21 patients at six sites. Standard protocols were used for MOCART evaluation at 1 week (baseline) 1, 3, 6, 12, 18 and 24 months. Multi-echo SE was used for T2 mapping. Global (T2 in RT divided by T2 in normal cartilage) and zonal T2 index (deep T2 divided by superficial T2) of RT were calculated. RESULTS: Average MOCART score was 71.8 (95% CI 62.2 to 81.3) at six, 75.2 (95% CI 62.8 to 87.5) at twelve, 71.8 (95% CI 55.4 to 88.2) at eighteen and 84.4 (95% CI 77.7 to 91.0) at twenty-four months. The global T2 index ranged between 0.8 and 1.2 (normal healthy cartilage) in 1/11 (9%) patients at baseline, 8/12 (67%) at 12 months, 11/13 (85%) at 18 months and 13/16 (81%) at 24 months. The zonal T2 index for RT was <20% difference to the zonal T2 index for normal cartilage in: 6/12 patients (50%) at 12 months, 7/13 (53.8%) at 18 months and 10/16 (63.5%) at 24 months. The standard deviation for T2 showed a significant decrease over the study. CONCLUSIONS: The increase of MOCART scores over follow-up indicates improving cartilage repair tissue. Global and zonal T2 repair values at 24 months reached normal cartilage in 81% and 63.5% of the patients respectively, reflecting collagen organization similar to hyaline cartilage.
Authors: Andrea Lazik; Jens M Theysohn; Christina Geis; Sören Johst; Mark E Ladd; Harald H Quick; Oliver Kraff Journal: Eur Radiol Date: 2015-08-28 Impact factor: 5.315
Authors: Martin Brix; Martin Kaipel; Richard Kellner; Markus Schreiner; Sebastian Apprich; Harald Boszotta; Reinhard Windhager; Stephan Domayer; Siegfried Trattnig Journal: Int Orthop Date: 2016-01-23 Impact factor: 3.075
Authors: Oliver Kraff; Andrea Lazik-Palm; Rahel Heule; Jens M Theysohn; Oliver Bieri; Harald H Quick Journal: MAGMA Date: 2016-04-25 Impact factor: 2.310
Authors: Flavia Cobianchi Bellisari; Luigi De Marino; Francesco Arrigoni; Silvia Mariani; Federico Bruno; Pierpaolo Palumbo; Camilla De Cataldo; Ferruccio Sgalambro; Nadia Catallo; Luigi Zugaro; Ernesto Di Cesare; Alessandra Splendiani; Carlo Masciocchi; Andrea Giovagnoni; Antonio Barile Journal: Radiol Med Date: 2021-05-18 Impact factor: 3.469
Authors: Markus M Schreiner; Marcus Raudner; Stefan Marlovits; Klaus Bohndorf; Michael Weber; Martin Zalaudek; Sebastian Röhrich; Pavol Szomolanyi; Giuseppe Filardo; Reinhard Windhager; Siegfried Trattnig Journal: Cartilage Date: 2019-08-17 Impact factor: 4.634