Literature DB >> 26187343

Evaluation of relationship between GRM3 polymorphisms and cognitive function in schizophrenia of Han Chinese.

Ming Chang1, Linyan Sun2, Xinmei Liu2, Wei Sun2, Ming Ji3, Zhenhong Wang3, Yonghui Wang3, Xuqun You4.   

Abstract

Recently, the novel SNP rs12704290 in GRM3 was identified in a genome-wide association study on schizophrenia susceptibility. Our study was to investigate the association of 29 selected SNPs (including rs12704290) with schizophrenia and to evaluate any possible relationship between them and cognition related to schizophrenia. The SNPs were analyzed in 1115 unrelated schizophrenic patients and 2289 healthy controls. The results showed significant associations between these SNPs and schizophrenia as well as with changes in cognition.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Cognitive function; Glutamate receptor; Schizophrenia susceptibility

Mesh：

Substances：

Year:  2015        PMID： 26187343     DOI： 10.1016/j.psychres.2015.06.012

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  6 in total

1.  mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks.

Authors:  Lu E Jin; Min Wang; Veronica C Galvin; Taber C Lightbourne; Peter Jeffrey Conn; Amy F T Arnsten; Constantinos D Paspalas
Journal:  Cereb Cortex       Date:  2018-03-01       Impact factor: 5.357

Review 2.  Metabotropic Glutamate Receptors As Emerging Targets for the Treatment of Schizophrenia.

Authors:  Shalini Dogra; P Jeffrey Conn
Journal:  Mol Pharmacol       Date:  2022-03-03       Impact factor: 4.054

3.  Meta-analysis supports GWAS-implicated link between GRM3 and schizophrenia risk.

Authors:  S M Saini; S G Mancuso; Md S Mostaid; C Liu; C Pantelis; I P Everall; C A Bousman
Journal:  Transl Psychiatry       Date:  2017-08-08       Impact factor: 6.222

Review 4.  Essential genetic findings in neurodevelopmental disorders.

Authors:  Ana R Cardoso; Mónica Lopes-Marques; Raquel M Silva; Catarina Serrano; António Amorim; Maria J Prata; Luísa Azevedo
Journal:  Hum Genomics       Date:  2019-07-09       Impact factor: 4.639

5.  Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex.

Authors:  Elizabeth Woo; Dibyadeep Datta; Amy F T Arnsten
Journal:  Front Neuroanat       Date:  2022-04-04       Impact factor: 3.543

6.  mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions.

Authors:  L E Jin; M Wang; S-T Yang; Y Yang; V C Galvin; T C Lightbourne; D Ottenheimer; Q Zhong; J Stein; A Raja; C D Paspalas; A F T Arnsten
Journal:  Mol Psychiatry       Date:  2016-08-09       Impact factor: 15.992
  6 in total

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