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Literature DB >> 26187331

Commentary: IL-4 and IL-13 receptors and signaling.

Abstract

Interleukin (IL)-4 and IL-13 were discovered approximately 30years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Interleukin-13; Interleukin-4; Receptor; Regulation; Singling

Mesh：

Substances：

Year: 2015 PMID： 26187331 PMCID： PMC4546937 DOI： 10.1016/j.cyto.2015.05.023

Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861

178 in total

1. Neuro-oncology: a step towards clinical blood biomarkers of glioblastoma.

Authors: Matthias Preusser
Journal: Nat Rev Neurol Date: 2014-11-04 Impact factor: 42.937

2. Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.

Authors: Michael O Daines; Yasuhiro Tabata; Bradley A Walker; Weiguo Chen; Manoj R Warrier; Saswata Basu; Gurjit K Khurana Hershey
Journal: J Immunol Date: 2006-06-15 Impact factor: 5.422

3. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population.

Authors: E Noguchi; M Shibasaki; T Arinami; K Takeda; T Maki; T Miyamoto; T Kawashima; K Kobayashi; H Hamaguchi
Journal: Am J Respir Crit Care Med Date: 1997-11 Impact factor: 21.405

4. An atopy-associated polymorphism in the ectodomain of the IL-4R(alpha) chain (V50) regulates the persistence of STAT6 phosphorylation.

Authors: Andrew Q Ford; Nicola M Heller; Linda Stephenson; Mark R Boothby; Achsah D Keegan
Journal: J Immunol Date: 2009-07-10 Impact factor: 5.422

5. IL-13R alpha 2 membrane and soluble isoforms differ in humans and mice.

Authors: Weiguo Chen; Umasundari Sivaprasad; Yasuhiro Tabata; Aaron M Gibson; Matthew T Stier; Fred D Finkelman; Gurjit K Khurana Hershey
Journal: J Immunol Date: 2009-12-15 Impact factor: 5.422

Review 6. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.

Authors: Miranda A Hallett; Katherine T Venmar; Barbara Fingleton
Journal: Cancer Res Date: 2012-12-07 Impact factor: 12.701

7. TSC1 controls macrophage polarization to prevent inflammatory disease.

Authors: Linnan Zhu; Tao Yang; Longjie Li; Lina Sun; Yuzhu Hou; Xuelian Hu; Lianjun Zhang; Hongling Tian; Qingjie Zhao; Jianxia Peng; Hongbing Zhang; Ruoyu Wang; Zhongzhou Yang; Lianfeng Zhang; Yong Zhao
Journal: Nat Commun Date: 2014-09-01 Impact factor: 14.919

8. Paradoxical effects of rapamycin on experimental house dust mite-induced asthma.

Authors: Karin Fredriksson; Jill A Fielhaber; Jonathan K Lam; Xianglan Yao; Katharine S Meyer; Karen J Keeran; Gayle J Zywicke; Xuan Qu; Zu-Xi Yu; Joel Moss; Arnold S Kristof; Stewart J Levine
Journal: PLoS One Date: 2012-05-25 Impact factor: 3.240

9. IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.

Authors: Christopher A Lazarski; Jill Ford; Shoshana D Katzman; Alexander F Rosenberg; Deborah J Fowell
Journal: PLoS One Date: 2013-08-26 Impact factor: 3.240

10. AGEMAP: a gene expression database for aging in mice.

Authors: Jacob M Zahn; Suresh Poosala; Art B Owen; Donald K Ingram; Ana Lustig; Arnell Carter; Ashani T Weeraratna; Dennis D Taub; Myriam Gorospe; Krystyna Mazan-Mamczarz; Edward G Lakatta; Kenneth R Boheler; Xiangru Xu; Mark P Mattson; Geppino Falco; Minoru S H Ko; David Schlessinger; Jeffrey Firman; Sarah K Kummerfeld; William H Wood; Alan B Zonderman; Stuart K Kim; Kevin G Becker
Journal: PLoS Genet Date: 2007-10-02 Impact factor: 5.917

77 in total

1. IL-1Rahigh-IL-4low-IL-13low: A Novel Plasma Cytokine Signature Associated with Olfactory Dysfunction in Older US Adults.

Authors: Eli P Darnell; Kristen E Wroblewski; Kristina L Pagel; David W Kern; Martha K McClintock; Jayant M Pinto
Journal: Chem Senses Date: 2020-05-29 Impact factor: 3.160

2. Interleukin-4 Signaling Plays a Major Role in Urogenital Schistosomiasis-Associated Bladder Pathogenesis.

Authors: Evaristus C Mbanefo; Chi-Ling Fu; Christina P Ho; Loc Le; Kenji Ishida; Olfat Hammam; Michael H Hsieh
Journal: Infect Immun Date: 2020-02-20 Impact factor: 3.441

Review 3. Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies.

Authors: Joshua S Davis; David Ferreira; Emma Paige; Craig Gedye; Michael Boyle
Journal: Clin Microbiol Rev Date: 2020-06-10 Impact factor: 26.132

4. Soluble interleukin-13rα1: a circulating regulator of glucose.

Authors: Inbal Rachmin; Caitlin C O'Meara; Elisabeth M Ricci-Blair; Yilin Feng; Emily M Christensen; Jeanne F Duffy; Kirsi M Zitting; Charles A Czeisler; James R Pancoast; Christopher P Cannon; Michelle L O'Donoghue; David A Morrow; Richard T Lee
Journal: Am J Physiol Endocrinol Metab Date: 2017-09-05 Impact factor: 4.310

Review 5. Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis.

Authors: Claire E Witherel; Daniel Abebayehu; Thomas H Barker; Kara L Spiller
Journal: Adv Healthc Mater Date: 2019-01-18 Impact factor: 9.933

Review 6. Cytokines and Chemokines in Mycobacterium tuberculosis Infection.

Authors: Racquel Domingo-Gonzalez; Oliver Prince; Andrea Cooper; Shabaana A Khader
Journal: Microbiol Spectr Date: 2016-10

7. The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation.

Authors: Preeta Dasgupta; Nicolas J Dorsey; Jiaqi Li; Xiulan Qi; Elizabeth P Smith; Kazuyo Yamaji-Kegan; Achsah D Keegan
Journal: Sci Signal Date: 2016-06-21 Impact factor: 8.192