Literature DB >> 26186863

Ultrasonic-accelerated rapid protocol for the improved synthesis of pyrazoles.

Nhlanhla Gracious Shabalala1, Ramakanth Pagadala1, Sreekantha B Jonnalagadda2.   

Abstract

A simple, catalyst-free, green synthetic protocol is described for the one-pot synthesis of pyrazoles via multicomponent reaction of aromatic aldehydes, hydrazine monohydrate and ethyl acetoacetate and malononitrile/ammonium acetate in water under ultrasound irradiation. This protocol avoids traditional chromatography and purification steps and it affords highly selective conversion with no byproducts.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Multicomponent reaction (MCR); One-pot synthesis; Pyrazole derivatives; Ultrasound; Water as solvent

Year:  2015        PMID： 26186863     DOI： 10.1016/j.ultsonch.2015.06.005

Source DB:  PubMed          Journal:  Ultrason Sonochem        ISSN： 1350-4177            Impact factor:   7.491


  5 in total

Review 1.  Sonochemical Protocols for Heterocyclic Synthesis: A Representative Review.

Authors:  Meena Devi; Rahul Singh; Jayant Sindhu; Ashwani Kumar; Sohan Lal; Ramesh Kumar; Khalid Hussain; Megha Sachdeva; Devender Singh; Parvin Kumar
Journal:  Top Curr Chem (Cham)       Date:  2022-02-12

2.  Urease covalently immobilized on cotton-derived nanocellulose-dialdehyde for urea detection and urea-based multicomponent synthesis of tetrahydro-pyrazolopyridines in water.

Authors:  Fatemeh Tamaddon; Davood Arab
Journal:  RSC Adv       Date:  2019-12-17       Impact factor: 3.361

3.  Mesoporous halloysite nanotubes modified by CuFe2O4 spinel ferrite nanoparticles and study of its application as a novel and efficient heterogeneous catalyst in the synthesis of pyrazolopyridine derivatives.

Authors:  Ali Maleki; Zoleikha Hajizadeh; Peyman Salehi
Journal:  Sci Rep       Date:  2019-04-03       Impact factor: 4.379

Review 4.  Ultrasound for Drug Synthesis: A Green Approach.

Authors:  Micheline Draye; Gregory Chatel; Romain Duwald
Journal:  Pharmaceuticals (Basel)       Date:  2020-01-31

5.  Catalyst-free synthesis of tetrahydrodipyrazolopyridines via an one-pot tandem and green pseudo-six-component reaction in water.

Authors:  Mina Keihanfar; Bi Bi Fatemeh Mirjalili
Journal:  BMC Chem       Date:  2022-03-04
  5 in total

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