Mayka Freire1, María Alonso2, Alberto Rivera2, Adrián Sousa2, Adriana Soto2, Jose Manuel Gómez-Sousa2, Aida Baroja2, Caritina Vázquez-Triñanes2, Bernardo Sopeña3. 1. Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Vigo (CHUVI), Planta 11, c/Pizarro 22, Vigo 36204, Spain. Electronic address: Maria.carmen.freire.dapena@sergas.es. 2. Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Vigo (CHUVI), Planta 11, c/Pizarro 22, Vigo 36204, Spain. 3. Thrombosis and Vasculitis Unit, Complexo Hospitalario Universitario de Santiago (CHUS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Abstract
OBJECTIVE: There are few data regarding the existence of clinical differences between patients with systemic sclerosis (scleroderma) exposed to silica (SSc-si) and "idiopathic" cases (SSc-id). Our goal is to describe the clinical characteristics of patients with SSc-si and see if they differ from the SSc-id cases. METHODS: We performed a systematic review of the literature by searching the MEDLINE, EMBASE and Web of Science databases. We also included our own series of patients diagnosed with SSc-si and SSc-id controls at the "Complejo Hospitalario Universitario de Vigo (CHUVI)" from 1985 to January 2013. RESULTS: The review of the literature disclosed 32 published series, with clinical data of 254 SSc-si patients (96% males). SSc-si represented 37.5-86% of the scleroderma males and 0-2.7% of the scleroderma females. Globally, more than expected proportion of diffuse forms (61%) and interstitial lung disease (81%) were observed in exposed patients. In the present series, the diagnosis of SSc exposure to silica was recorded in nine patients (9.5%), showing predominance of the diffuse form (77%, p = 0.001), positivity for anti-Scl70 (55%, p = 0.001), presence of ILD (78%, p = 0.048) and lower survival (9.2 versus 15.1, p = 0.023). Diffuse variant remained more prevalent analysing exposed versus non-exposed women (50% versus 8%, p = 0,000) and exposed versus non-exposed men (85.8% versus 50%, p = 0,000). CONCLUSION: Silica exposure is a predominant risk factor in male SSc populations. The review of the literature is consistent with an association of SSc-si and diffuse scleroderma. A trend toward lower survival was observed in our series in SSc-si group.
OBJECTIVE: There are few data regarding the existence of clinical differences between patients with systemic sclerosis (scleroderma) exposed to silica (SSc-si) and "idiopathic" cases (SSc-id). Our goal is to describe the clinical characteristics of patients with SSc-si and see if they differ from the SSc-id cases. METHODS: We performed a systematic review of the literature by searching the MEDLINE, EMBASE and Web of Science databases. We also included our own series of patients diagnosed with SSc-si and SSc-id controls at the "Complejo Hospitalario Universitario de Vigo (CHUVI)" from 1985 to January 2013. RESULTS: The review of the literature disclosed 32 published series, with clinical data of 254 SSc-si patients (96% males). SSc-si represented 37.5-86% of the scleroderma males and 0-2.7% of the scleroderma females. Globally, more than expected proportion of diffuse forms (61%) and interstitial lung disease (81%) were observed in exposed patients. In the present series, the diagnosis of SSc exposure to silica was recorded in nine patients (9.5%), showing predominance of the diffuse form (77%, p = 0.001), positivity for anti-Scl70 (55%, p = 0.001), presence of ILD (78%, p = 0.048) and lower survival (9.2 versus 15.1, p = 0.023). Diffuse variant remained more prevalent analysing exposed versus non-exposed women (50% versus 8%, p = 0,000) and exposed versus non-exposed men (85.8% versus 50%, p = 0,000). CONCLUSION:Silica exposure is a predominant risk factor in male SSc populations. The review of the literature is consistent with an association of SSc-si and diffuse scleroderma. A trend toward lower survival was observed in our series in SSc-si group.
Authors: Evelien De Decker; Marie Vanthuyne; Daniel Blockmans; Frederic Houssiau; Jan Lenaerts; Rene Westhovens; Benoit Nemery; Ellen De Langhe Journal: Clin Rheumatol Date: 2018-02-23 Impact factor: 2.980
Authors: Jae Yoon Kim; Sang Yoon Do; Young Hoon Moon; Chul Gab Lee; Yun Sung Kim; Byung Soon Choi; Eun-A Kim; Han Soo Song Journal: Ann Occup Environ Med Date: 2017-06-19