Tania P Markovic1, Ros Muirhead2, Shannon Overs2, Glynis P Ross3, Jimmy Chun Yu Louie2, Nathalie Kizirian2, Gareth Denyer4, Peter Petocz5, Jon Hyett6, Jennie C Brand-Miller2. 1. The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia tania.markovic@sydney.edu.au. 2. The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia. 3. Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia Sydney Medical School, The University of Sydney, Sydney, NSW, Australia. 4. Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia. 5. Department of Statistics, Macquarie University, Sydney, NSW, Australia. 6. RPA Women and Babies, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Abstract
OBJECTIVE:Dietary interventions can improve pregnancy outcomes in women with gestational diabetes mellitus (GDM). We compared the effect of a low-glycemic index (GI) versus a conventional high-fiber (HF) diet on pregnancy outcomes, birth weight z score, and maternal metabolic profile in women at high risk of GDM. RESEARCH DESIGN AND METHODS: One hundred thirty-nine women [mean (SD) age 34.7 (0.4) years and prepregnancy BMI25.2 (0.5) kg/m(2)] were randomly assigned to a low-GI (LGI) diet (n = 72; target GI ∼50) or a high-fiber, moderate-GI (HF) diet (n = 67; target GI ∼60) at 14-20 weeks' gestation. Diet was assessed by 3-day food records and infant body composition by air-displacement plethysmography, and pregnancy outcomes were assessed from medical records. RESULTS: The LGI group achieved a lower GI than the HF group [mean (SD) 50 (5) vs. 58 (5); P < 0.001]. There were no differences in glycosylated hemoglobin, fructosamine, or lipids at 36 weeks or differences in birth weight [LGI 3.4 (0.4) kg vs. HF 3.4 (0.5) kg; P = 0.514], birth weight z score [LGI 0.31 (0.90) vs. HF 0.24 (1.07); P = 0.697], ponderal index [LGI 2.71 (0.22) vs. HF 2.69 (0.23) kg/m(3); P = 0.672], birth weight centile [LGI 46.2 (25.4) vs. HF 41.8 (25.6); P = 0.330], % fat mass [LGI 10 (4) vs. HF 10 (4); P = 0.789], or incidence of GDM. CONCLUSIONS: In intensively monitored women at risk for GDM, a low-GI diet and a healthy diet produce similar pregnancy outcomes.
RCT Entities:
OBJECTIVE: Dietary interventions can improve pregnancy outcomes in women with gestational diabetes mellitus (GDM). We compared the effect of a low-glycemic index (GI) versus a conventional high-fiber (HF) diet on pregnancy outcomes, birth weight z score, and maternal metabolic profile in women at high risk of GDM. RESEARCH DESIGN AND METHODS: One hundred thirty-nine women [mean (SD) age 34.7 (0.4) years and prepregnancy BMI 25.2 (0.5) kg/m(2)] were randomly assigned to a low-GI (LGI) diet (n = 72; target GI ∼50) or a high-fiber, moderate-GI (HF) diet (n = 67; target GI ∼60) at 14-20 weeks' gestation. Diet was assessed by 3-day food records and infant body composition by air-displacement plethysmography, and pregnancy outcomes were assessed from medical records. RESULTS: The LGI group achieved a lower GI than the HF group [mean (SD) 50 (5) vs. 58 (5); P < 0.001]. There were no differences in glycosylated hemoglobin, fructosamine, or lipids at 36 weeks or differences in birth weight [LGI 3.4 (0.4) kg vs. HF 3.4 (0.5) kg; P = 0.514], birth weight z score [LGI 0.31 (0.90) vs. HF 0.24 (1.07); P = 0.697], ponderal index [LGI 2.71 (0.22) vs. HF 2.69 (0.23) kg/m(3); P = 0.672], birth weight centile [LGI 46.2 (25.4) vs. HF 41.8 (25.6); P = 0.330], % fat mass [LGI 10 (4) vs. HF 10 (4); P = 0.789], or incidence of GDM. CONCLUSIONS: In intensively monitored women at risk for GDM, a low-GI diet and a healthy diet produce similar pregnancy outcomes.
Authors: Carla Assaf-Balut; Nuria García de la Torre; Alejandra Duran; Manuel Fuentes; Elena Bordiú; Laura Del Valle; Cristina Familiar; Johanna Valerio; Inés Jiménez; Miguel A Herraiz; Nuria Izquierdo; María J Torrejon; Maria Ángeles Cuadrado; Isabel Ortega; Francisco J Illana; Isabelle Runkle; Paz de Miguel; Inmaculada Moraga; Carmen Montañez; Ana Barabash; Martín Cuesta; Miguel A Rubio; Alfonso L Calle-Pascual Journal: Ann Nutr Metab Date: 2018-12-14 Impact factor: 3.374
Authors: Nathalie V Kizirian; Tania P Markovic; Roslyn Muirhead; Shannon Brodie; Sarah P Garnett; Jimmy C Y Louie; Peter Petocz; Glynis P Ross; Jennie C Brand-Miller Journal: Nutrients Date: 2016-05-06 Impact factor: 5.717