Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.

Literature DB >> 26185209

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.

Peipei Ping¹, Åsa B Gustafsson¹, Don M Bers¹, Lothar A Blatter¹, Hua Cai¹, Arshad Jahangir¹, Daniel Kelly¹, Deborah Muoio¹, Brian O'Rourke¹, Peter Rabinovitch¹, Natalia Trayanova¹, Jennifer Van Eyk¹, James N Weiss¹, Renee Wong¹, Lisa Schwartz Longacre².

Abstract

Mitochondrial biology is the sum of diverse phenomena from molecular profiles to physiological functions. A mechanistic understanding of mitochondria in disease development, and hence the future prospect of clinical translations, relies on a systems-level integration of expertise from multiple fields of investigation. Upon the successful conclusion of a recent National Institutes of Health, National Heart, Lung, and Blood Institute initiative on integrative mitochondrial biology in cardiovascular diseases, we reflect on the accomplishments made possible by this unique interdisciplinary collaboration effort and exciting new fronts on the study of these remarkable organelles.

Entities: CellLine Chemical Disease Gene Species

Keywords: National Heart, Lung, and Blood Institute (U.S.); cardiovascular disease; cell death; heart diseases; mitochondria

Mesh：

Year: 2015 PMID： 26185209 PMCID： PMC4535701 DOI： 10.1161/CIRCRESAHA.117.306693

Source DB: PubMed Journal: Circ Res ISSN： 0009-7330 Impact factor: 17.367

12 in total

1. Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy.

Authors: Dao-Fu Dai; Tony Chen; Hazel Szeto; Madeline Nieves-Cintrón; Vassily Kutyavin; Luis F Santana; Peter S Rabinovitch
Journal: J Am Coll Cardiol Date: 2011-05-27 Impact factor: 24.094

2. Protective role of transient pore openings in calcium handling by cardiac mitochondria.

Authors: Paavo Korge; Ling Yang; Jun-Hai Yang; Yibin Wang; Zhilin Qu; James N Weiss
Journal: J Biol Chem Date: 2011-08-22 Impact factor: 5.157

3. Topograph, a software platform for precursor enrichment corrected global protein turnover measurements.

Authors: Edward J Hsieh; Nicholas J Shulman; Dao-Fu Dai; Evelyn S Vincow; Pabalu P Karunadharma; Leo Pallanck; Peter S Rabinovitch; Michael J MacCoss
Journal: Mol Cell Proteomics Date: 2012-08-03 Impact factor: 5.911

4. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.

Authors: Ting Liu; Eiki Takimoto; Veronica L Dimaano; Deeptankar DeMazumder; Sarah Kettlewell; Godfrey Smith; Agnieszka Sidor; Theodore P Abraham; Brian O'Rourke
Journal: Circ Res Date: 2014-04-29 Impact factor: 17.367

5. Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry.

Authors: Emirhan Nemutlu; Song Zhang; Anu Gupta; Nenad O Juranic; Slobodan I Macura; Andre Terzic; Arshad Jahangir; Petras Dzeja
Journal: Physiol Genomics Date: 2012-01-10 Impact factor: 3.107

6. Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.

Authors: Xiyuan Lu; Kenneth S Ginsburg; Sarah Kettlewell; Julie Bossuyt; Godfrey L Smith; Donald M Bers
Journal: Circ Res Date: 2012-12-14 Impact factor: 17.367

7. A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Authors: Ola J Martin; Ling Lai; Mangala M Soundarapandian; Teresa C Leone; Antonio Zorzano; Mark P Keller; Alan D Attie; Deborah M Muoio; Daniel P Kelly
Journal: Circ Res Date: 2013-12-23 Impact factor: 17.367

Review 8. Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.

Authors: Gregory Aubert; Rick B Vega; Daniel P Kelly
Journal: Biochim Biophys Acta Date: 2012-08-31

9. Integration of cardiac proteome biology and medicine by a specialized knowledgebase.

Authors: Nobel C Zong; Haomin Li; Hua Li; Maggie P Y Lam; Rafael C Jimenez; Christina S Kim; Ning Deng; Allen K Kim; Jeong Ho Choi; Ivette Zelaya; David Liem; David Meyer; Jacob Odeberg; Caiyun Fang; Hao-Jie Lu; Tao Xu; James Weiss; Huilong Duan; Mathias Uhlen; John R Yates; Rolf Apweiler; Junbo Ge; Henning Hermjakob; Peipei Ping
Journal: Circ Res Date: 2013-08-21 Impact factor: 17.367

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative.

1. Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy.

2. Protective role of transient pore openings in calcium handling by cardiac mitochondria.

3. Topograph, a software platform for precursor enrichment corrected global protein turnover measurements.

4. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.

5. Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry.

6. Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release.

7. A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth.

Review 8. Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart.

9. Integration of cardiac proteome biology and medicine by a specialized knowledgebase.

10. Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.

1. Late onset MELAS with m.3243A > G mutation and its association with aneurysm formation.

2. MMP9 inhibition increases autophagic flux in chronic heart failure.

Review 3. Mitochondrial involvement in myocyte death and heart failure.

4. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.

Review 5. Quality Matters? The Involvement of Mitochondrial Quality Control in Cardiovascular Disease.

Review 6. Recent advances in understanding cardiac contractility in health and disease.