Indira García-Cordero1, Lucas Sedeño1, Daniel Fraiman1, Damian Craiem1, Laura Alethia de la Fuente1, Paula Salamone1, Cecilia Serrano1, Luciano Sposato1, Facundo Manes1, Agustín Ibañez2. 1. From the Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina (I.G.-G., L.S., L.A.d.l.F., P.S., F.M., A.I.); UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, Chile (L.S., F.M., A.I.); National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina (L.S., D.F., D.C., F.M., A.I.); Laboratorio de Investigación en Neurociencia, Universidad de San Andrés, Buenos Aires, Argentina (D.F.); Facultad de Ingeniería, Ciencias Exactas y Naturales, Universidad Favaloro, Buenos Aires, Argentina (D.C.); Memory and Balance Clinic, Buenos Aires, Argentina (C.S.); Department of Clinical Neurological Sciences, Western University, London, Canada (L.S.); Universidad Autónoma del Caribe, Barranquilla, Colombia (A.I.); and ACR Centre of Excellence in Cognition and its Disorders, Sydney, Australia (F.M., A.I.). 2. From the Laboratory of Experimental Psychology and Neuroscience (LPEN), Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina (I.G.-G., L.S., L.A.d.l.F., P.S., F.M., A.I.); UDP-INECO Foundation Core on Neuroscience (UIFCoN), Faculty of Psychology, Diego Portales University, Santiago, Chile (L.S., F.M., A.I.); National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina (L.S., D.F., D.C., F.M., A.I.); Laboratorio de Investigación en Neurociencia, Universidad de San Andrés, Buenos Aires, Argentina (D.F.); Facultad de Ingeniería, Ciencias Exactas y Naturales, Universidad Favaloro, Buenos Aires, Argentina (D.C.); Memory and Balance Clinic, Buenos Aires, Argentina (C.S.); Department of Clinical Neurological Sciences, Western University, London, Canada (L.S.); Universidad Autónoma del Caribe, Barranquilla, Colombia (A.I.); and ACR Centre of Excellence in Cognition and its Disorders, Sydney, Australia (F.M., A.I.). aibanez@ineco.org.ar.
Abstract
BACKGROUND AND PURPOSE: Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. METHODS: Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. RESULTS: Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. CONCLUSIONS: Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
BACKGROUND AND PURPOSE:Stroke and neurodegeneration cause significant brain damage and cognitive impairment, especially if the insular cortex is compromised. This study explores for the first time whether these 2 causes differentially alter connectivity patterns in the insular cortex. METHODS: Resting state-functional magnetic resonance imaging data were collected from patients with insular stroke, patients with behavioral variant frontotemporal dementia, and healthy controls. Data from the 3 groups were assessed through a correlation function analysis. Specifically, we compared decreases in connectivity as a function of voxel Euclidean distance within the insular cortex. RESULTS: Relative to controls, patients with stroke showed faster connectivity decays as a function of distance (hypoconnectivity). In contrast, the behavioral variant frontotemporal dementia group exhibited significant hyperconnectivity between neighboring voxels. Both patient groups evinced global hypoconnectivity. No between-group differences were observed in a volumetrically and functionally comparable region without ischemia or neurodegeneration. CONCLUSIONS: Functional insular cortex connectivity is affected differently by cerebral ischemia and neurodegeneration, possibly because of differences in the cause-specific pathophysiological mechanisms of each disease. These findings have important clinical and theoretical implications.
Authors: Indira García-Cordero; Lucas Sedeño; Laura de la Fuente; Andrea Slachevsky; Gonzalo Forno; Francisco Klein; Patricia Lillo; Jesica Ferrari; Clara Rodriguez; Julian Bustin; Teresa Torralva; Sandra Baez; Adrian Yoris; Sol Esteves; Margherita Melloni; Paula Salamone; David Huepe; Facundo Manes; Adolfo M García; Agustín Ibañez Journal: Philos Trans R Soc Lond B Biol Sci Date: 2016-10-10 Impact factor: 6.237
Authors: Lucas Sedeño; Olivier Piguet; Sofía Abrevaya; Horacio Desmaras; Indira García-Cordero; Sandra Baez; Laura Alethia de la Fuente; Pablo Reyes; Sicong Tu; Sebastian Moguilner; Nicolas Lori; Ramon Landin-Romero; Diana Matallana; Andrea Slachevsky; Teresa Torralva; Dante Chialvo; Fiona Kumfor; Adolfo M García; Facundo Manes; John R Hodges; Agustin Ibanez Journal: Hum Brain Mapp Date: 2017-05-05 Impact factor: 5.038
Authors: Maria Luisa Mandelli; Ariane E Welch; Eduard Vilaplana; Christa Watson; Giovanni Battistella; Jesse A Brown; Katherine L Possin; Honey I Hubbard; Zachary A Miller; Maya L Henry; Gabe A Marx; Miguel A Santos-Santos; Lynn P Bajorek; Juan Fortea; Adam Boxer; Gil Rabinovici; Suzee Lee; Jessica Deleon; Howard J Rosen; Bruce L Miller; William W Seeley; Maria Luisa Gorno-Tempini Journal: Cortex Date: 2018-08-11 Impact factor: 4.027
Authors: D Fraiman; M F Miranda; F Erthal; P F Buur; M Elschot; L Souza; S A R B Rombouts; C A Schimmelpenninck; D G Norris; M J A Malessy; A Galves; C D Vargas Journal: Neuroimage Clin Date: 2016-07-26 Impact factor: 4.881