| Literature DB >> 26184899 |
Ismail Kucukkurt1, Sinan Ince2, Hasan Huseyin Demirel3, Ruhi Turkmen2, Erten Akbel4, Yasemin Celik5.
Abstract
The aim of the present study was to investigate the possible protective effects of boron, an antioxidant agent, against arsenic-induced oxidative stress in male and female rats. In total, 42 Wistar albino male and female rats were divided into three equal groups: The animals in the control group were given normal drinking water, the second group was given drinking water with 100 mg/L arsenic, and the third group was orally administered drinking water with 100 mg/kg boron together with arsenic. At the end of the 28-day experiment, arsenic increased lipid peroxidation and damage in the tissues of rats. However, boron treatment reversed this arsenic-induced lipid peroxidation and activities of antioxidant enzymes in rats. Moreover, boron exhibited a protective action against arsenic-induced histopathological changes in the tissues of rats. In conclusion, boron was found to be effective in protecting rats against arsenic-induced lipid peroxidation by enhancing antioxidant defense mechanisms.Entities:
Keywords: Antioxidant Enzymes; Arsenic: Boron; Lipid Peroxidation; Rat
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Year: 2015 PMID： 26184899 DOI： 10.1002/jbt.21729
Source DB: PubMed Journal: J Biochem Mol Toxicol ISSN： 1095-6670 Impact factor: 3.642