Literature DB >> 26184559

Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery.

Malgosia M Pakulska1,2, Katarina Vulic3, Roger Y Tam1,2, Molly S Shoichet1,2,3.   

Abstract

Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  design of experiment; drug delivery; hydrogels; rheology; spinal cord injuries

Mesh：

Substances：

Year:  2015        PMID： 26184559     DOI： 10.1002/adma.201502767

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  14 in total

1.  Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules.

Authors:  Yingkai Liang; Kristi L Kiick
Journal:  Biomacromolecules       Date:  2016-01-25       Impact factor: 6.988

Review 2.  Hydrogels for brain repair after stroke: an emerging treatment option.

Authors:  Lina Ratiba Nih; Stanley Thomas Carmichael; Tatiana Segura
Journal:  Curr Opin Biotechnol       Date:  2016-05-07       Impact factor: 9.740

Review 3.  Composites of Polymer Hydrogels and Nanoparticulate Systems for Biomedical and Pharmaceutical Applications.

Authors:  Fuli Zhao; Dan Yao; Ruiwei Guo; Liandong Deng; Anjie Dong; Jianhua Zhang
Journal:  Nanomaterials (Basel)       Date:  2015-12-03       Impact factor: 5.076

4.  Norbornene-functionalized methylcellulose as a thermo- and photo-responsive bioink.

Authors:  Min Hee Kim; Chien-Chi Lin
Journal:  Biofabrication       Date:  2021-09-21       Impact factor: 11.061

Review 5.  Evolution of drug-eluting biomedical implants for sustained drug delivery.

Authors:  Juliana C Quarterman; Sean M Geary; Aliasger K Salem
Journal:  Eur J Pharm Biopharm       Date:  2020-12-16       Impact factor: 5.589

Review 6.  Biomaterials for Local, Controlled Drug Delivery to the Injured Spinal Cord.

Authors:  Alexis M Ziemba; Ryan J Gilbert
Journal:  Front Pharmacol       Date:  2017-05-10       Impact factor: 5.810

7.  Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes.

Authors:  Zi-Xian Liao; Meng-Chia Liu; Ivan M Kempson; Yu-Chen Fa; Kuo-Yen Huang
Journal:  Int J Nanomedicine       Date:  2017-10-17

8.  From waste of marine culture to natural patch in cardiac tissue engineering.

Authors:  Yutong He; Honghao Hou; Shuqi Wang; Rurong Lin; Leyu Wang; Lei Yu; Xiaozhong Qiu
Journal:  Bioact Mater       Date:  2020-12-30

9.  Encapsulation-free controlled release: Electrostatic adsorption eliminates the need for protein encapsulation in PLGA nanoparticles.

Authors:  Malgosia M Pakulska; Irja Elliott Donaghue; Jaclyn M Obermeyer; Anup Tuladhar; Christopher K McLaughlin; Tyler N Shendruk; Molly S Shoichet
Journal:  Sci Adv       Date:  2016-05-27       Impact factor: 14.136

Review 10.  Hydrogel-assisted neuroregeneration approaches towards brain injury therapy: A state-of-the-art review.

Authors:  Vladimir A Kornev; Ekaterina A Grebenik; Anna B Solovieva; Ruslan I Dmitriev; Peter S Timashev
Journal:  Comput Struct Biotechnol J       Date:  2018-11-02       Impact factor: 7.271
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