| Literature DB >> 26183563 |
Tomohiko Fukuda1, Osamu Wada-Hiraike2, Katsutoshi Oda1, Michihiro Tanikawa1, Chinami Makii1, Kanako Inaba1, Aki Miyasaka1, Yuichiro Miyamoto1, Tetsu Yano3, Daichi Maeda4, Takeshi Sasaki4, Kei Kawana1, Masashi Fukayama4, Yutaka Osuga1, Tomoyuki Fujii1.
Abstract
SIRT6, a member of the sirtuin family, has been identified as a candidate tumor suppressor. To pursue the role of SIRT6 in endometrial cancer, we investigated the anti-tumorigenic function of SIRT6. The expression of SIRT6 negatively affected the proliferation of AN3CA and KLE endometrial cancer cells. Increased expression of SIRT6 resulted in the induction of apoptosis by repressing the expression of the anti-apoptotic protein survivin. Consistent with this result, a survivin inhibitor YM155 efficiently inhibited cellular proliferation and induced apoptosis. These results revealed that SIRT6 might function as a tumor suppressor of endometrial cancer cells.Entities:
Keywords: Apoptosis; Endometrial cancer; SIRT6; Survivin; YM155
Mesh：
Substances：
Year: 2015 PMID： 26183563 DOI： 10.1016/j.febslet.2015.06.043
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 3.864