Literature DB >> 26183083

The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity.

Rosivaldo S Borges1, Steven L Castle2.   

Abstract

The synthesis and antioxidant evaluation by DPPH scavenging of a series of salicylic acid derivatives is described. Gentisic acid and its ester, amide, and amino analogs possess more radical scavenging capacity than salicylic acid and other salicylate derivatives. This property can possibly provide an additional pathway for anti-inflammatory activity through either single electron or hydrogen atom transfer, leading to a new strategy for the design of anti-inflammatory agents.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anti-inflammatory; Antioxidant mechanism; DFT; DPPH(); Salicylate derivatives

Mesh：

Substances：

Year:  2015        PMID： 26183083     DOI： 10.1016/j.bmcl.2015.07.001

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Synthesis of salicylic acid phenylethyl ester (SAPE) and its implication in immunomodulatory and anticancer roles.

Authors:  Arup Jyoti Das; Monoj Kumar Das; Salam Pradeep Singh; Partha Pratim Saikia; Neelu Singh; Johirul Islam; Aftab Ansari; Pronobesh Chattopadhyay; Paulraj Rajamani; Tatsuro Miyaji; Sankar Chandra Deka
Journal:  Sci Rep       Date:  2022-05-24       Impact factor: 4.996

Review 2.  Mechanisms of Colorectal Cancer Prevention by Aspirin-A Literature Review and Perspective on the Role of COX-Dependent and -Independent Pathways.

Authors:  Ranjini Sankaranarayanan; D Ramesh Kumar; Meric A Altinoz; G Jayarama Bhat
Journal:  Int J Mol Sci       Date:  2020-11-27       Impact factor: 5.923

3.  Bioactive Earthworm Peptides Produced by Novel Protease-Producing Bacillus velezensis PM 35 and Its Bioactivities on Liver Cancer Cell Death via Apoptosis, Antioxidant Activity, Protection Against Oxidative Stress, and Immune Cell Activation.

Authors:  Pimphan Wasunan; Chutamas Maneewong; Wichittra Daengprok; Mongkol Thirabunyanon
Journal:  Front Microbiol       Date:  2022-08-10       Impact factor: 6.064

4.  Myeloperoxidase Inhibitory and Antioxidant Activities of (E)-2-Hydroxy-α-aminocinnamic Acids Obtained through Microwave-Assisted Synthesis.

Authors:  Astrid Rivera-Antonio; Martha Cecilia Rosales-Hernández; Irving Balbuena-Rebolledo; José Martín Santiago-Quintana; Jessica Elena Mendieta-Wejebe; José Correa-Basurto; Juan Benjamín García-Vázquez; Efrén Venancio García-Báez; Itzia I Padilla-Martínez
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-27

5.  Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.

Authors:  Maria V Grishchenko; Galina F Makhaeva; Yanina V Burgart; Elena V Rudakova; Natalia P Boltneva; Nadezhda V Kovaleva; Olga G Serebryakova; Sofya V Lushchekina; Tatiana Y Astakhova; Ekaterina F Zhilina; Evgeny V Shchegolkov; Rudy J Richardson; Victor I Saloutin
Journal:  ChemMedChem       Date:  2022-03-23       Impact factor: 3.540
  5 in total

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