Qingqing Pan1, Jian Li2, Fang Li3, Daobin Zhou2, Zhaohui Zhu1. 1. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and. 2. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 3. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; and lifangpumch@126.com.
Abstract
UNLABELLED: POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes) syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The patients usually present with multisystemic involvement. Thus, we performed a study to investigate the role of (18)F-FDG PET/CT in characterizing POEMS syndrome. METHODS: Ninety-one untreated patients with proven or suspected POEMS syndrome were recruited to undergo (18)F-FDG PET/CT. Features of bone lesions, lymphadenopathy, hepatomegaly or splenomegaly, bone marrow, and serous cavity effusion were examined, and 15 patients were followed up with PET/CT scans 3 mo after therapy. RESULTS: Of the 90 patients diagnosed with POEMS syndrome, there were 140 (18)F-FDG-avid bone lesions. These lesions were frequently found in the pelvis, and most showed mixed characteristics. Four patients showed enlarged and (18)F-FDG-avid lymph nodes. Sixty-five patients had hepatomegaly or splenomegaly. Some of them had hypermetabolic spleen and bone marrow. Forty-six patients had serous cavity effusion. Five male patients had gynecomastia. Three months after therapy, (18)F-FDG-avid bone lesions showed decreased metabolism. CONCLUSION: (18)F-FDG PET/CT is a useful tool for the evaluation of patients with suspected POEMS syndrome. (18)F-FDG PET/CT may contribute to the diagnosis, evaluation, and follow-up of patients with POEMS syndrome by providing systematic findings of bone lesions, lymphadenopathy, liver or spleen involvement, serous cavity effusion, and the metabolic status of the lesions.
UNLABELLED: POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein elevation, and skin changes) syndrome is a rare paraneoplastic syndrome caused by an underlying plasma cell disorder. The patients usually present with multisystemic involvement. Thus, we performed a study to investigate the role of (18)F-FDG PET/CT in characterizing POEMS syndrome. METHODS: Ninety-one untreated patients with proven or suspected POEMS syndrome were recruited to undergo (18)F-FDG PET/CT. Features of bone lesions, lymphadenopathy, hepatomegaly or splenomegaly, bone marrow, and serous cavity effusion were examined, and 15 patients were followed up with PET/CT scans 3 mo after therapy. RESULTS: Of the 90 patients diagnosed with POEMS syndrome, there were 140 (18)F-FDG-avid bone lesions. These lesions were frequently found in the pelvis, and most showed mixed characteristics. Four patients showed enlarged and (18)F-FDG-avid lymph nodes. Sixty-five patients had hepatomegaly or splenomegaly. Some of them had hypermetabolic spleen and bone marrow. Forty-six patients had serous cavity effusion. Five male patients had gynecomastia. Three months after therapy, (18)F-FDG-avid bone lesions showed decreased metabolism. CONCLUSION: (18)F-FDG PET/CT is a useful tool for the evaluation of patients with suspected POEMS syndrome. (18)F-FDG PET/CT may contribute to the diagnosis, evaluation, and follow-up of patients with POEMS syndrome by providing systematic findings of bone lesions, lymphadenopathy, liver or spleen involvement, serous cavity effusion, and the metabolic status of the lesions.
Authors: Michael S Clark; Benjamin M Howe; Katrina N Glazebrook; Michelle L Mauermann; Stephen M Broski Journal: Skeletal Radiol Date: 2017-03-25 Impact factor: 2.199
Authors: T V Kourelis; F K Buadi; M A Gertz; M Q Lacy; S K Kumar; P Kapoor; R S Go; J A Lust; S R Hayman; V Rajkumar; S R Zeldenrust; S J Russell; D Dingli; Y Lin; N Leung; Y L Hwa; W Gonsalves; R A Kyle; A Dispenzieri Journal: Leukemia Date: 2015-12-16 Impact factor: 11.528
Authors: Jose Rafael Infante; Lucía García; Juan Ignacio Rayo; Justo Serrano; Manuel Moreno; Amparo Cobo; Pedro Jimenez; Andrés Martínez Journal: Indian J Nucl Med Date: 2019 Jan-Mar