| Literature DB >> 26182322 |
Yoshimasa Hashimoto1,2, Daisuke Miyaki3,4, Eisuke Murakami3, Yuko Nagaoki3, Yuki Kimura3, Azakami Takahiro3, Yoshio Katamura3, Tomokazu Kawaoka3, Shintaro Takaki3, Masataka Tsuge3, Nobuhiko Hiraga3, Akira Hiramatsu3, Koji Waki3, Michio Imamura3, Hiroshi Aikata3, Shoichi Takahashi3, Koji Arihiro5, Hideki Ohdan6, Kazuaki Chayama3.
Abstract
A 68-year-old Japanese woman with chronic hepatitis C infection who achieved sustained viral response (SVR) was followed up regularly. Six years after SVR, alpha fetoprotein (AFP) was increased. Hepatocellular carcinoma (HCC) was diagnosed by computed tomography and was excised by hepatic resection. Thirteen years after SVR, AFP increased again, and HCC recurrence was detected, which was excised by hepatic resection. Each HCC was <2 cm in diameter, with no vascular invasion. The primary HCC was moderately differentiated, while the secondary was well-to-moderately differentiated. Based on the clinicopathological features, the hepatocarcinogenesis was considered multicentric. Our case illustrates the importance of long-term follow-up of patients who achieve SVR.Entities:
Keywords: Carcinogenesis; HCC; IFN; Recurrence; SVR
Year: 2012 PMID： 26182322 DOI： 10.1007/s12328-012-0303-8
Source DB: PubMed Journal: Clin J Gastroenterol ISSN： 1865-7265