Liangkun Ma1, Hong Qi2, Xiaofeng Chai3, Fang Jiang1, Su Mao1, Juntao Liu1, Shaoqin Zhang2, Xiaolan Lian3, Xiujing Sun4, Danhua Wang4, Jie Ren5, Qi Yan5. 1. a Department of Obstetrics and Gynecology , Peking Union Medical College Hospital , Beijing , China . 2. b Prenatal Screening Center, Department of Obstetrics and Gynecology, Haidian Maternal & Child Health Hospital , Beijing , China . 3. c Department of Endocrinology , Endocrinal Key Laboratory of Ministry of Health, Peking Union Medical College Hospital , Beijing , China . 4. d Department of Pediatrics , Peking Union Medical College Hospital , Beijing , China , and. 5. e Early Child Health and Development Centre, Haidian Maternal & Child Health Hospital , Beijing , China.
Abstract
PURPOSE: To evaluate the effect of subclinical hypothyroidism (SCH) screening and intervention on pregnancy outcomes and explore the significance of thyroid function during early pregnancy. METHODS:Pregnant women were recruited from Peking Union Medical College Hospital (screening group for measuring thyroid function and thyroid antibody in early pregnancy) and Haidian Maternal & Child Health Hospital (control group whose serum was stored and measured shortly after delivery) from July 2011 to December 2012. Thyrotropin levels 2.5-10 mIU/L and free T4 levels in normal range were considered SCH. Some of the screening group were treated with levothyroxine and adjusted. The others did not take medicine but kept a regular follow-up visit to doctors after antenatal clinic. The pregnancy outcomes and complications were compared. RESULTS:1671 women (675 in screening group and 996 in control group) were recruited. 419 (167 from screening group) women was diagnosed as SCH. In screening group, 105 SCH and 4 hypothyroid women received thyroid hormone replacement therapy. The miscarriage and fetal macrosomia risks were lower, and cesarean was higher in screening group than control. CONCLUSION:Screening and intervention of SCH can significantly reduce the incidence rate of miscarriage.
RCT Entities:
PURPOSE: To evaluate the effect of subclinical hypothyroidism (SCH) screening and intervention on pregnancy outcomes and explore the significance of thyroid function during early pregnancy. METHODS: Pregnant women were recruited from Peking Union Medical College Hospital (screening group for measuring thyroid function and thyroid antibody in early pregnancy) and Haidian Maternal & Child Health Hospital (control group whose serum was stored and measured shortly after delivery) from July 2011 to December 2012. Thyrotropin levels 2.5-10 mIU/L and free T4 levels in normal range were considered SCH. Some of the screening group were treated with levothyroxine and adjusted. The others did not take medicine but kept a regular follow-up visit to doctors after antenatal clinic. The pregnancy outcomes and complications were compared. RESULTS: 1671 women (675 in screening group and 996 in control group) were recruited. 419 (167 from screening group) women was diagnosed as SCH. In screening group, 105 SCH and 4 hypothyroidwomen received thyroid hormone replacement therapy. The miscarriage and fetal macrosomia risks were lower, and cesarean was higher in screening group than control. CONCLUSION: Screening and intervention of SCH can significantly reduce the incidence rate of miscarriage.
Entities:
Keywords:
Pregnancy outcome; subclinical hypothyroidism; thyroid function tests
Authors: Kemal Beksaç; Fatih Aktoz; Gökçen Örgül; Hasan Tolga Çelik; A Seval Özgü-Erdinç; M Sinan Beksaç Journal: J Turk Ger Gynecol Assoc Date: 2018-02-20
Authors: Mihaela Țarnă; Luminița Nicoleta Cima; Anca Maria Panaitescu; Carmen Sorina Martin; Anca Elena Sîrbu; Carmen Gabriela Barbu; Bogdan Pavel; Andreea Nicoleta Șerbănică; Simona Fica Journal: Medicina (Kaunas) Date: 2022-08-18 Impact factor: 2.948