Literature DB >> 26180454

A Rare Association of Childhood Alopecia Areata and Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome: Successfully Treated with Diphenylcyclopropenone.

Soumya Jagadeesan1, Pradeep Balasubramanian2, Vinitha Varghese Panicker1, Gopikrishnan Anjaneyan1, Jacob Thomas1.   

Abstract

The genetic background of alopecia areata has only recently begun to get unraveled. We report the association of a case of pediatric alopecia areata with a rare genetic syndrome-blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), which responded well to topical immunotherapy with diphenylcyclopropenone. In the background of increasing evidence surfacing on the genetic basis of alopecia areata, this association may be of significance.

Entities:  

Keywords:  Alopecia areata; blepharophimosis-ptosis-epicanthus inversus syndrome; contact immunotherapy; diphenylcyclopropenone; genetic basis

Year:  2015        PMID： 26180454      PMCID： PMC4502480          DOI： 10.4103/0974-7753.160118

Source DB:  PubMed          Journal:  Int J Trichology        ISSN： 0974-7753


  5 in total

1.  Alopecia areata in children: treatment with diphencyprone.

Authors:  M L Schuttelaar; J J Hamstra; E P Plinck; J D Peereboom-Wynia; V D Vuzevski; P G Mulder; A P Oranje
Journal:  Br J Dermatol       Date:  1996-10       Impact factor: 9.302

Review 2.  Genetic basis of alopecia areata: a roadmap for translational research.

Authors:  Ali Jabbari; Lynn Petukhova; Rita M Cabral; Raphael Clynes; Angela M Christiano
Journal:  Dermatol Clin       Date:  2012-10-23       Impact factor: 3.478

3.  Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation.

Authors:  Diane Beysen; Lara Moumné; Reiner Veitia; Hartmut Peters; Bart P Leroy; Anne De Paepe; Elfride De Baere
Journal:  Hum Mol Genet       Date:  2008-03-27       Impact factor: 6.150

4.  Single nucleotide polymorphisms in the promoter regions of Foxp3 and ICOSLG genes are associated with Alopecia areata.

Authors:  G Conteduca; A Rossi; F Megiorni; A Parodi; F Ferrera; S Tardito; F Battaglia; F Kalli; S Negrini; A Pizzuti; E Rizza; F Indiveri; D Fenoglio; G Filaci
Journal:  Clin Exp Med       Date:  2012-11-30       Impact factor: 3.984

5.  Missense mutation outside the forkhead domain of FOXL2 causes a severe form of BPES type II.

Authors:  Alireza Haghighi; Hannah Verdin; Hamidreza Haghighi-Kakhki; Niloofar Piri; Nasrollah Saleh Gohari; Elfride De Baere
Journal:  Mol Vis       Date:  2012-01-26       Impact factor: 2.367
  5 in total
  1 in total

1.  Follicular Dowling-Degos Disease and Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome: A Chance or Significant Association.

Authors:  Pramila Kumari; Swastika Suvirya; Atin Singhai; Kiranpreet Malhotra; Sucheta Pathania
Journal:  Indian J Dermatol       Date:  2021 Jan-Feb       Impact factor: 1.494
  1 in total

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