Literature DB >> 26179399

New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity.

Da-Hong Li1, Tong Han1, Li-Ping Guan1, Jiao Bai1, Nan Zhao1, Zhan-Lin Li1, Xin Wu2, Hui-Ming Hua1.   

Abstract

A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2-9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of new compound 1 was elucidated on the basis of its spectroscopic data (1D, 2D NMR and CD). Compound 1 exhibited moderate inhibitory activity against the human lung adenocarcinoma A549 and the human leukaemia HL-60 cell lines. Compound 5 displayed significant in vitro antiproliferative activity against HL-60 cell line with an IC50 value of 0.8 μM.

Entities:  

Keywords:  Aspergillus niger; antiproliferative activity; dimeric naphthopyrones

Mesh：

Substances：

Year:  2015        PMID： 26179399     DOI： 10.1080/14786419.2015.1043553

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  8 in total

1.  Penicacids H-J, three new mycophenolic acid derivatives from the marine-derived fungus Rhizopus oryzae.

Authors:  Amine Dilara Pilevneli; Sherif S Ebada; Banu Kaşkatepe; Belma Konuklugil
Journal:  RSC Adv       Date:  2021-11-01       Impact factor: 3.361

Review 2.  Recent updates on the bioactive compounds of the marine-derived genus Aspergillus.

Authors:  Raha Orfali; Mahmoud A Aboseada; Nada M Abdel-Wahab; Hossam M Hassan; Shagufta Perveen; Fuad Ameen; Eman Alturki; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2021-05-11       Impact factor: 4.036

3.  Anti-Trichomonas vaginalis activity and chemical analysis of metabolites produced by marine-associated fungi.

Authors:  Franciane Rios Senger; Rodrigo Campos-Silva; Melissa Fontes Landell; Denise Brentan Silva; Camila Braz Menezes; Graziela Vargas Rigo; Laura Nunes Silva; Danielle Silva Trentin; Alexandre José Macedo; Tiana Tasca
Journal:  Parasitol Res       Date:  2022-02-03       Impact factor: 2.289

4.  Aromatic Polyketides from a Symbiotic Strain Aspergillus fumigatus D and Characterization of Their Biosynthetic Gene D8.t287.

Authors:  Yi Hua; Rui Pan; Xuelian Bai; Bin Wei; Jianwei Chen; Hong Wang; Huawei Zhang
Journal:  Mar Drugs       Date:  2020-06-20       Impact factor: 5.118

Review 5.  Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei.

Authors:  Jens C Frisvad; Lars L H Møller; Thomas O Larsen; Ravi Kumar; José Arnau
Journal:  Appl Microbiol Biotechnol       Date:  2018-10-06       Impact factor: 4.813

Review 6.  Overview on antibacterial metabolites from terrestrial Aspergillus spp.

Authors:  Abdulkawi Ali Al-Fakih; Wael Qasem Abdulgabbar Almaqtri
Journal:  Mycology       Date:  2019-04-22

7.  Pigmentosins from Gibellula sp. as antibiofilm agents and a new glycosylated asperfuran from Cordyceps javanica.

Authors:  Soleiman E Helaly; Wilawan Kuephadungphan; Patima Phainuphong; Mahmoud A A Ibrahim; Kanoksri Tasanathai; Suchada Mongkolsamrit; Janet Jennifer Luangsa-Ard; Souwalak Phongpaichit; Vatcharin Rukachaisirikul; Marc Stadler
Journal:  Beilstein J Org Chem       Date:  2019-12-16       Impact factor: 2.883

Review 8.  Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.

Authors:  Anton N Yurchenko; Elena V Girich; Ekaterina A Yurchenko
Journal:  Mar Drugs       Date:  2021-02-04       Impact factor: 5.118
  8 in total

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