Mirjam Langeveld1, J Hans DeVries2. 1. Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. 2. Department of Endocrinology, Academic Medical Center, Amsterdam, The Netherlands.
Abstract
OBJECTIVE: To quantify the effectiveness of diet interventions by systematic review of the long-term effects of energy restricted diets in individuals with overweight and obesity. METHODS: A systematic literature search was conducted for all clinical trials studying the effect of energy restricted diets on body weight in individuals with a BMI>25 kg/m(2) with a follow-up of at least 3 years and a minimum of 50 participants. Weight change from baseline and rates of loss to follow-up at the longest follow-up were extracted and analyzed using random-effects models. RESULTS: Weighted mean weight loss after 3 years follow-up was 3.5% (95% CI 0.2-6.8%) (n = 6,163) and after 4 years follow-up 4.5% (95% CI 4.3-4.8%) (n = 5,696). Energy restricted diets (n = 1,433) resulted in an average 2.9% (95% CI -3.8 to -2.1%) greater weight loss compared to untreated control groups (n = 1,361). Weight regain was observed in the majority of individuals in all studies. Interpretation of the data is limited by high rates of loss to follow-up and lack of truly untreated control groups. CONCLUSIONS: On average, the long-term effect of diets on body weight in individuals with obesity is modest, and the response is highly heterogeneous.
OBJECTIVE: To quantify the effectiveness of diet interventions by systematic review of the long-term effects of energy restricted diets in individuals with overweight and obesity. METHODS: A systematic literature search was conducted for all clinical trials studying the effect of energy restricted diets on body weight in individuals with a BMI>25 kg/m(2) with a follow-up of at least 3 years and a minimum of 50 participants. Weight change from baseline and rates of loss to follow-up at the longest follow-up were extracted and analyzed using random-effects models. RESULTS: Weighted mean weight loss after 3 years follow-up was 3.5% (95% CI 0.2-6.8%) (n = 6,163) and after 4 years follow-up 4.5% (95% CI 4.3-4.8%) (n = 5,696). Energy restricted diets (n = 1,433) resulted in an average 2.9% (95% CI -3.8 to -2.1%) greater weight loss compared to untreated control groups (n = 1,361). Weight regain was observed in the majority of individuals in all studies. Interpretation of the data is limited by high rates of loss to follow-up and lack of truly untreated control groups. CONCLUSIONS: On average, the long-term effect of diets on body weight in individuals with obesity is modest, and the response is highly heterogeneous.
Authors: Selwyn van Rijn; Yvonne G M Roebroek; Charlotte de Jonge; Jan Willem M Greve; Nicole D Bouvy Journal: Obes Surg Date: 2019-04 Impact factor: 4.129
Authors: Christopher C Thompson; Barham K Abu Dayyeh; Robert Kushner; Shelby Sullivan; Alan B Schorr; Anastassia Amaro; Caroline M Apovian; Terrence Fullum; Amir Zarrinpar; Michael D Jensen; Adam C Stein; Steven Edmundowicz; Michel Kahaleh; Marvin Ryou; J Matthew Bohning; Gregory Ginsberg; Christopher Huang; Daniel D Tran; Joseph P Glaser; John A Martin; David L Jaffe; Francis A Farraye; Samuel B Ho; Nitin Kumar; Donna Harakal; Meredith Young; Catherine E Thomas; Alpana P Shukla; Michele B Ryan; Miki Haas; Heidi Goldsmith; Jennifer McCrea; Louis J Aronne Journal: Am J Gastroenterol Date: 2016-12-06 Impact factor: 10.864