Literature DB >> 26178980

2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.

Jayeeta Dhar1, Rolando A Cuevas2, Ramansu Goswami1, Jianzhong Zhu2, Saumendra N Sarkar3, Sailen Barik4.   

Abstract

2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome-dependent degradation of specific OASL isoforms. We conclude that OASL acts as a cellular antiviral protein and that RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26178980      PMCID： PMC4577923          DOI： 10.1128/JVI.01076-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  39 in total

1.  Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response.

Authors:  J Schlender; B Bossert; U Buchholz; K K Conzelmann
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

2.  Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees.

Authors:  M N Teng; S S Whitehead; A Bermingham; M St Claire; W R Elkins; B R Murphy; P L Collins
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

3.  Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo.

Authors:  H Jin; H Zhou; X Cheng; R Tang; M Munoz; N Nguyen
Journal:  Virology       Date:  2000-07-20       Impact factor: 3.616

4.  Gene structure of the murine 2'-5'-oligoadenylate synthetase family.

Authors:  S Eskildsen; R Hartmann; N O Kjeldgaard; J Justesen
Journal:  Cell Mol Life Sci       Date:  2002-07       Impact factor: 9.261

5.  Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins.

Authors:  Jean-Francois Valarcher; Julie Furze; Sara Wyld; Roy Cook; Karl-Klaus Conzelmann; Geraldine Taylor
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

6.  Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3.

Authors:  Birgit Bossert; Sabrina Marozin; Karl-Klaus Conzelmann
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

7.  Evaluation of recombinant respiratory syncytial virus gene deletion mutants in African green monkeys for their potential as live attenuated vaccine candidates.

Authors:  Hong Jin; Xing Cheng; Vicki L Traina-Dorge; Hyun Jung Park; Helen Zhou; Ken Soike; George Kemble
Journal:  Vaccine       Date:  2003-09-08       Impact factor: 3.641

8.  Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.

Authors:  Signe Eskildsen; Just Justesen; Mikkel Heide Schierup; Rune Hartmann
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

9.  Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected].

Authors:  Kirsten M Spann; Kim-C Tran; Bo Chi; Ronald L Rabin; Peter L Collins
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

10.  Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses.

Authors:  V Bitko; S Barik
Journal:  BMC Microbiol       Date:  2001-12-20       Impact factor: 3.605
View more
  18 in total

1.  Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production.

Authors:  Arundhati Ghosh; Lulu Shao; Padmavathi Sampath; Baoyu Zhao; Nidhi V Patel; Jianzhong Zhu; Bharat Behl; Robert A Parise; Jan H Beumer; Roderick J O'Sullivan; Neal A DeLuca; Stephen H Thorne; Vijay A K Rathinam; Pingwei Li; Saumendra N Sarkar
Journal:  Immunity       Date:  2019-01-08       Impact factor: 31.745

2.  Mining GWAS and eQTL data for CF lung disease modifiers by gene expression imputation.

Authors:  Hong Dang; Deepika Polineni; Rhonda G Pace; Jaclyn R Stonebraker; Harriet Corvol; Garry R Cutting; Mitchell L Drumm; Lisa J Strug; Wanda K O'Neal; Michael R Knowles
Journal:  PLoS One       Date:  2020-11-30       Impact factor: 3.240

3.  Identification of 2'-5'-Oligoadenylate Synthetase-Like Gene in Goose: Gene Structure, Expression Patterns, and Antiviral Activity Against Newcastle Disease Virus.

Authors:  Chao Yang; Fei Liu; Shun Chen; Mingshu Wang; Renyong Jia; Dekang Zhu; Mafeng Liu; Kunfeng Sun; Qiao Yang; Ying Wu; Xiaoyue Chen; Anchun Cheng
Journal:  J Interferon Cytokine Res       Date:  2016-09       Impact factor: 2.607

4.  Molecular Cloning and Identification of the 2'-5' Oligoadenylate Synthetase 2 Gene in Chinese Domestic Pigs Through Bioinformatics Analysis, and Determination of Its Antiviral Activity Against Porcine Reproductive and Respiratory Syndrome Virus Infection.

Authors:  Ruining Wang; Hongfang Ma; Yinfeng Kang; Cunfa Li; Huawei Li; Erqin Zhang; Pengchao Ji; Jian He; Mengmeng Zhao
Journal:  Indian J Microbiol       Date:  2018-04-26       Impact factor: 2.461

5.  Unique nonstructural proteins of Pneumonia Virus of Mice (PVM) promote degradation of interferon (IFN) pathway components and IFN-stimulated gene proteins.

Authors:  Jayeeta Dhar; Sailen Barik
Journal:  Sci Rep       Date:  2016-12-01       Impact factor: 4.379

6.  OASL1 Traps Viral RNAs in Stress Granules to Promote Antiviral Responses.

Authors:  Ji-Seon Kang; Yune-Sahng Hwang; Lark Kyun Kim; Sujung Lee; Wook-Bin Lee; Jeongsil Kim-Ha; Young-Joon Kim
Journal:  Mol Cells       Date:  2018-02-21       Impact factor: 5.034

7.  Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals.

Authors:  Enguang Rong; Xiaoxue Wang; Hualan Chen; Chenghuai Yang; Jiaxiang Hu; Wenjie Liu; Zeng Wang; Xiaoyun Chen; Haixue Zheng; Juan Pu; Honglei Sun; Jacqueline Smith; David W Burt; Jinhua Liu; Ning Li; Yinhua Huang
Journal:  Front Immunol       Date:  2018-06-20       Impact factor: 7.561

8.  A balanced game: chicken macrophage response to ALV-J infection.

Authors:  Min Feng; Tingting Xie; Yuanfang Li; Nan Zhang; Qiuyuan Lu; Yaohong Zhou; Meiqing Shi; Jingchen Sun; Xiquan Zhang
Journal:  Vet Res       Date:  2019-03-06       Impact factor: 3.683

Review 9.  Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity.

Authors:  Gisela Canedo-Marroquín; Orlando Acevedo-Acevedo; Emma Rey-Jurado; Juan M Saavedra; Margarita K Lay; Susan M Bueno; Claudia A Riedel; Alexis M Kalergis
Journal:  Front Cell Infect Microbiol       Date:  2017-08-16       Impact factor: 5.293

10.  Conserved Active-Site Residues Associated with OAS Enzyme Activity and Ubiquitin-Like Domains Are Not Required for the Antiviral Activity of goOASL Protein against Avian Tembusu Virus.

Authors:  Shun Chen; Chao Yang; Jinyue Zhang; Zhen Wu; Mingshu Wang; Renyong Jia; Dekang Zhu; Mafeng Liu; Qiao Yang; Ying Wu; Xinxin Zhao; Shaqiu Zhang; Yunya Liu; Ling Zhang; Yanling Yu; Yu You; Anchun Cheng
Journal:  Viruses       Date:  2018-07-15       Impact factor: 5.048
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.