Yan Zhang1, Daiquan Gao2, Hong Ye2, Yingying Su2. 1. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Email: zhangylq@sina.com. 2. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Abstract
OBJECTIVE: To explore the safety of plasma exchange (PE) therapy in patients with anti-NMDA receptor encephalitis. METHODS: Prospective reviews were conducted for the adverse events and therapeutic efficacies of PE therapy in 9 patients with anti-NMDA receptor encephalitis admitted into neuro-intensive care unit from January 2012 to January 2015. RESULTS: A total of 54 PE procedures were performed. The NMDA receptor antibody titer of cerebrospinal fluid (CSF) and/or sera in 9 patients (100%) decreased or turned negative. Five patients (55.5%) demonstrated clinical improvement after PE therapy. And clinical complications included frequent involuntary movements, hypotension, coagulation of PE channel, febricity, allergic response and errhysis around peripheral venous access. CONCLUSION: PE is effective, safe and well-tolerated in patients with anti-NMDA receptor encephalitis.
OBJECTIVE: To explore the safety of plasma exchange (PE) therapy in patients with anti-NMDA receptor encephalitis. METHODS: Prospective reviews were conducted for the adverse events and therapeutic efficacies of PE therapy in 9 patients with anti-NMDA receptor encephalitis admitted into neuro-intensive care unit from January 2012 to January 2015. RESULTS: A total of 54 PE procedures were performed. The NMDA receptor antibody titer of cerebrospinal fluid (CSF) and/or sera in 9 patients (100%) decreased or turned negative. Five patients (55.5%) demonstrated clinical improvement after PE therapy. And clinical complications included frequent involuntary movements, hypotension, coagulation of PE channel, febricity, allergic response and errhysis around peripheral venous access. CONCLUSION: PE is effective, safe and well-tolerated in patients with anti-NMDA receptor encephalitis.
Authors: Monica Gomes Ferreira; Victoria Lapresa Alcalde; María Helena García Sánchez; Lourdes Hernández Hernández; María José Doyague Sánchez Journal: Medicine (Baltimore) Date: 2018-08 Impact factor: 1.817