Vanina S Kanoore Edul1,2,3, Can Ince3, Elisa Estenssoro4, Gonzalo Ferrara1,4, Yanina Arzani5, Carolina Salvatori6, Arnaldo Dubin1,6. 1. Cátedra de Farmacología Aplicada, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Argentina. 2. Hospital Fernández, Buenos Aires, Argentina. 3. Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4. Hospital San Martín, La Plata, Argentina. 5. Sanatorio Las Lomas, San Isidro, Buenos Aires, Argentina. 6. Sanatorio Otamendi y Miroli, Buenos Aires, Argentina.
Abstract
OBJECTIVES: To quantitatively assess the effects of age, blood pressure, chronic arterial hypertension, and physical activity on sublingual microcirculation in ambulatory volunteers. METHODS: Sublingual microcirculation was assessed in 61 volunteers with or without chronic arterial hypertension. RESULTS: Volunteers with chronic arterial hypertension had lower TVD all vessels, and TVD small vessels and PVD small vessels than those without this condition (16.0 ± 1.4 vs. 17.2 ± 1.6 mm/mm(2), p < 0.01, 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm(2), p < 0.04, and 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm(2), p < 0.04, respectively). Mean blood pressure correlated with TVD all vessels (r = -0.34, p < 0.01), TVD small vessels (r = -0.31, p < 0.02), and PVD small vessels (r = -0.27, p < 0.04) but not with other microvascular variables. Age was not correlated with any microcirculatory variables. Physical activity correlated with TVDall vessels and RBCV small vessels (r = 0.30, p < 0.02 and r = -0.47, p < 0.001, respectively). Chronic arterial hypertension was the only independent determinant of PVD small vessels . CONCLUSIONS: Preexistent chronic arterial hypertension was associated with lower vascular densities. In contrast, age showed no effect on sublingual microcirculation.
OBJECTIVES: To quantitatively assess the effects of age, blood pressure, chronic arterial hypertension, and physical activity on sublingual microcirculation in ambulatory volunteers. METHODS: Sublingual microcirculation was assessed in 61 volunteers with or without chronic arterial hypertension. RESULTS: Volunteers with chronic arterial hypertension had lower TVD all vessels, and TVD small vessels and PVD small vessels than those without this condition (16.0 ± 1.4 vs. 17.2 ± 1.6 mm/mm(2), p < 0.01, 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm(2), p < 0.04, and 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm(2), p < 0.04, respectively). Mean blood pressure correlated with TVD all vessels (r = -0.34, p < 0.01), TVD small vessels (r = -0.31, p < 0.02), and PVD small vessels (r = -0.27, p < 0.04) but not with other microvascular variables. Age was not correlated with any microcirculatory variables. Physical activity correlated with TVDall vessels and RBCV small vessels (r = 0.30, p < 0.02 and r = -0.47, p < 0.001, respectively). Chronic arterial hypertension was the only independent determinant of PVD small vessels . CONCLUSIONS: Preexistent chronic arterial hypertension was associated with lower vascular densities. In contrast, age showed no effect on sublingual microcirculation.
Authors: Can Ince; E Christiaan Boerma; Maurizio Cecconi; Daniel De Backer; Nathan I Shapiro; Jacques Duranteau; Michael R Pinsky; Antonio Artigas; Jean-Louis Teboul; Irwin K M Reiss; Cesar Aldecoa; Sam D Hutchings; Abele Donati; Marco Maggiorini; Fabio S Taccone; Glenn Hernandez; Didier Payen; Dick Tibboel; Daniel S Martin; Alexander Zarbock; Xavier Monnet; Arnaldo Dubin; Jan Bakker; Jean-Louis Vincent; Thomas W L Scheeren Journal: Intensive Care Med Date: 2018-02-06 Impact factor: 17.440
Authors: Jihan Harki; Mustafa Suker; M Sherezade Tovar-Doncel; Louisa Jd van Dijk; Désirée van Noord; Casper Hj van Eijck; Marco J Bruno; Ernst J Kuipers; Can Ince Journal: Clin Exp Gastroenterol Date: 2018-10-18