Rong Ren1, Guoping Huang2, Jihui Zhang3, Junying Zhou1,3, Yun Li1, Yuanfeng Sun1, Guangyao Zhou1, Suxia Li4, Lin Lu4, Yun-Kwok Wing3, Xiangdong Tang5. 1. Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, Department of Otolaryngology, West China Hospital, Sichuan University, 28 Dian Xin Nan Jie, Chengdu City, 610041, Sichuan Province, China. 2. The Third Hospital of Mianyang, Mianyang, China. 3. Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region. 4. National Institute on Drug Dependence, Peking University Sixth Hospital/Institute of Mental Health and Key Laboratory of Mental Health, Peking University, Beijing, China. 5. Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, Department of Otolaryngology, West China Hospital, Sichuan University, 28 Dian Xin Nan Jie, Chengdu City, 610041, Sichuan Province, China. xiangdong.tang@gmail.com.
Abstract
PURPOSE: The aim of this study was to investigate gender differences of periodic limb movements during sleep (PLMS) in patients with obstructive sleep apnea (OSA). METHODS: This was a case-control study recruiting 364 patients with OSA (182 men, 182 women) matched for age and apnea-hypopnea index (AHI). All participants underwent overnight polysomnography (PSG), followed by the multiple sleep latency test (MSLT) and the Epworth Sleepiness Scale (ESS). RESULTS: Women with OSA had a significantly higher prevalence of PLMS than men (24.2 vs. 15.9 %, p < 0.05). Women with OSA showed an increased prevalence of PLMS compared to men in the younger group aged ≤55 years (23.0 vs. 10.6 %, p < 0.05), but not in the older groups >55 years (25.3 vs. 21.6 %, p > 0.05). Binary linear regression analysis in OSA patients confirmed that women were more likely to have PLMS than men (OR 1.71, 95 % CI 1.00-2.92), particularly in patients with age ≤55 years old (OR 2.48, 95 % CI 1.06-5.79), after adjusting for age, BMI, AHI, and habits of smoking and drinking. CONCLUSIONS: The results demonstrate that, for patients with OSA, young women had significantly increased prevalence of PLMS compared to young men, but there was no difference in prevalence of PLMS between the men and women in the older age group.
PURPOSE: The aim of this study was to investigate gender differences of periodic limb movements during sleep (PLMS) in patients with obstructive sleep apnea (OSA). METHODS: This was a case-control study recruiting 364 patients with OSA (182 men, 182 women) matched for age and apnea-hypopnea index (AHI). All participants underwent overnight polysomnography (PSG), followed by the multiple sleep latency test (MSLT) and the Epworth Sleepiness Scale (ESS). RESULTS:Women with OSA had a significantly higher prevalence of PLMS than men (24.2 vs. 15.9 %, p < 0.05). Women with OSA showed an increased prevalence of PLMS compared to men in the younger group aged ≤55 years (23.0 vs. 10.6 %, p < 0.05), but not in the older groups >55 years (25.3 vs. 21.6 %, p > 0.05). Binary linear regression analysis in OSA patients confirmed that women were more likely to have PLMS than men (OR 1.71, 95 % CI 1.00-2.92), particularly in patients with age ≤55 years old (OR 2.48, 95 % CI 1.06-5.79), after adjusting for age, BMI, AHI, and habits of smoking and drinking. CONCLUSIONS: The results demonstrate that, for patients with OSA, young women had significantly increased prevalence of PLMS compared to young men, but there was no difference in prevalence of PLMS between the men and women in the older age group.
Authors: Marco Zucconi; Raffaele Ferri; Richard Allen; Paul Christian Baier; Oliviero Bruni; Sudhansu Chokroverty; Luigi Ferini-Strambi; Stephany Fulda; Diego Garcia-Borreguero; Wayne A Hening; Max Hirshkowitz; Birgit Högl; Magdolna Hornyak; Martin King; Pasquale Montagna; Liborio Parrino; Giuseppe Plazzi; Mario G Terzano Journal: Sleep Med Date: 2006-02-03 Impact factor: 3.492
Authors: Brian B Koo; Terri Blackwell; Sonia Ancoli-Israel; Katie L Stone; Marcia L Stefanick; Susan Redline Journal: Circulation Date: 2011-08-22 Impact factor: 29.690
Authors: Louise M O'Brien; Julie Koo; Ludi Fan; Jocelynn T Owusu; Wattanachai Chotinaiwattarakul; Barbara T Felt; Ronald D Chervin Journal: J Clin Sleep Med Date: 2009-12-15 Impact factor: 4.062
Authors: David M Claman; Susan Redline; Terri Blackwell; Sonia Ancoli-Israel; Susan Surovec; Nancy Scott; Jane A Cauley; Kristine E Ensrud; Katie L Stone Journal: J Clin Sleep Med Date: 2006-10-15 Impact factor: 4.062
Authors: Hyeyun Kim; Kwang Ik Yang; Jun-Sang Sunwoo; Jongkyu Park; Nam Hun Heo; Jee Hyun Kim; Seung Bong Hong Journal: Int J Environ Res Public Health Date: 2022-04-14 Impact factor: 4.614