Francesco Cacciatore1,2, David Della-Morte3,4, Claudia Basile1, Francesco Curcio1, Ilaria Liguori1, Mario Roselli3, Gaetano Gargiulo5, Gianluigi Galizia1,6, Domenico Bonaduce1, Pasquale Abete1. 1. Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy. 2. IRCCS Salvatore Maugeri Foundation, Scientific Institute of Telese, Benevento, Italy. 3. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy. 4. IRCCS San Raffaele Pisana, Rome, Italy. 5. Division of Geriatrics, AON SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. 6. IRCCS Salvatore Maugeri Foundation, Scientific Institute of Veruno, Novara, Italy.
Abstract
AIMS: To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. METHODS: Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. RESULTS: b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis. CONCLUSIONS: b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.
AIMS: To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength. METHODS: Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment. RESULTS:b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis. CONCLUSIONS:b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.
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