Goran Loncar1, Verena Tscholl2,3, Elvis Tahirovic2, Nikola Sekularac1, Almuth Marx4, Danilo Obradovic2, Jovan Veskovic2, Mitja Lainscak5,6, Stephan von Haehling7,8, Frank Edelmann2, Aleksandra Arandjelovic1,9, Svetlana Apostolovic10, Dragana Stanojevic10, Burkert Pieske2, Tobias Trippel2, Hans-Dirk Dungen2. 1. Department of Cardiology, Clinical Hospital Zvezdara, Belgrade, Serbia. 2. Department of Cardiology, Campus Virchow, Charité Universitätsmedizin Berlin, Berlin, Germany. 3. Department of Cardiology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Germany. 4. Marx-Statistics, Nuremberg, Germany. 5. Departments of Cardiology & Research & Education, General Hospital Celje, Celje, Slovenia. 6. Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. 7. Department of Cardiology, Applied Cachexia Research, Charité Medical School, Berlin, Germany. 8. Center for Cardiovascular Research (CCR), Charité Medical School, Campus Mitte, Berlin, Germany. 9. School of Medicine, University of Belgrade, Serbia. 10. Clinic for Cardiovascular Diseases, Clinical Center Nis, Serbia.
Abstract
AIM: To elucidate the prognostic role of procalcitonin (PCT) in patients with acute decompensated heart failure (ADHF) without clinical signs of infection at admission. MATERIALS & METHODS: Serial measurements of PCT and NT-proBNP were performed in 168 patients, aged 68 ± 10 years with ADHF followed by 3-month outcome evaluation. RESULTS: Cox regression analysis demonstrated significant predictive value of baseline PCT for all-cause death/hospitalization (area under the curve: 0.67; p = 0.013) at 90th day. The patients with persistently elevated PCT or with an increase during the first 72 h of hospitalization had the worst prognosis (p = 0.0002). CONCLUSION: Baseline and serial in-hospital measurements of PCT have significant prognostic properties for 3-month all-cause mortality/hospitalization in patients with ADHF without clinical signs of infection at admission.
AIM: To elucidate the prognostic role of procalcitonin (PCT) in patients with acute decompensated heart failure (ADHF) without clinical signs of infection at admission. MATERIALS & METHODS: Serial measurements of PCT and NT-proBNP were performed in 168 patients, aged 68 ± 10 years with ADHF followed by 3-month outcome evaluation. RESULTS: Cox regression analysis demonstrated significant predictive value of baseline PCT for all-cause death/hospitalization (area under the curve: 0.67; p = 0.013) at 90th day. The patients with persistently elevated PCT or with an increase during the first 72 h of hospitalization had the worst prognosis (p = 0.0002). CONCLUSION: Baseline and serial in-hospital measurements of PCT have significant prognostic properties for 3-month all-cause mortality/hospitalization in patients with ADHF without clinical signs of infection at admission.
Entities:
Keywords:
ADHF; NT-proBNP; procalcitonin; prognosis; serial measurements
Authors: J Banach; Ł Wołowiec; D Rogowicz; L Gackowska; I Kubiszewska; W Gilewski; J Michałkiewicz; W Sinkiewicz Journal: Dis Markers Date: 2018-08-28 Impact factor: 3.434