Ahmed O Almobarak1, Salma Barakat2, Eltayeb A Suliman3, Wadie M Elmadhoun4, Nabeel A Mohamed5, Israa O Abobaker6, Sufian K Noor7, Sarra O Bushara7, Mohamed H Ahmed8. 1. Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan. 2. National Center for GI & Liver Diseases, Ibn Sina Hospital, Ministry of Health, Khartoum, Sudan. 3. Federal Ministry of Health, Khartoum, Sudan. 4. Department of Pathology, Faculty of Medicine, Nile Valley University, Atbara, Sudan. 5. Department of Medicine, Sentara Obici Hospital, Suffolk, VA, USA. 6. Department of Statistics, Faculty of Mathematical Sciences - University of Khartoum, Khartoum, Sudan. 7. Department of Medicine, Faculty of Medicine, Nile Valley University, Atbara, Sudan. 8. Department of Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK. Electronic address: elziber@yahoo.com.
Abstract
BACKGROUND AND STUDY AIM: Non-alcoholic fatty liver disease (NAFLD) is a common global chronic liver condition. The prevalence of NAFLD among individuals with type 2 diabetes is estimated to be as high as 75%. The aim of this study was to determine the prevalence of NAFLD among individuals with type 2 diabetes in Sudan. PATIENTS AND METHODS: This was a cross-sectional hospital-based study, which was carried out at the Jabir Abu-Elizz diabetic centre in Khartoum; 167 outpatients with type 2 diabetes were enrolled. NAFLD was diagnosed based on ultrasound, following exclusion of significant alcohol intake and secondary causes of liver diseases. NAFLD was defined as hepatic steatosis in the absence of alcohol intake, medication, previous liver disease and negative results for the serological test for hepatitis B and C. Logistic regression analysis was used to determine independent risk factors for the development of NAFLD in individuals with type 2 diabetes. RESULTS: The number of female subjects was 89 (53.3%), and most subjects (145, 86.8%) were between the ages of 40 and 70 years. The overall prevalence of fatty liver among individuals with type 2 diabetes was found to be 50.3%. Age, duration of diabetes, hypertension and HbA1c levels appeared to have no impact on the prevalence of NAFLD. The possible predictors of NAFLD were overweight, obesity, central obesity, high triglyceride level and low high-density lipoprotein cholesterol (HDL-c) level. A higher prevalence of NAFLD was observed in individuals with three components of the metabolic syndrome. CONCLUSION: NAFLD was observed in half of the diabetic population, and its occurrence correlates positively with metabolic syndrome risk factors.
BACKGROUND AND STUDY AIM: Non-alcoholic fatty liver disease (NAFLD) is a common global chronic liver condition. The prevalence of NAFLD among individuals with type 2 diabetes is estimated to be as high as 75%. The aim of this study was to determine the prevalence of NAFLD among individuals with type 2 diabetes in Sudan. PATIENTS AND METHODS: This was a cross-sectional hospital-based study, which was carried out at the Jabir Abu-Elizz diabetic centre in Khartoum; 167 outpatients with type 2 diabetes were enrolled. NAFLD was diagnosed based on ultrasound, following exclusion of significant alcohol intake and secondary causes of liver diseases. NAFLD was defined as hepatic steatosis in the absence of alcohol intake, medication, previous liver disease and negative results for the serological test for hepatitis B and C. Logistic regression analysis was used to determine independent risk factors for the development of NAFLD in individuals with type 2 diabetes. RESULTS: The number of female subjects was 89 (53.3%), and most subjects (145, 86.8%) were between the ages of 40 and 70 years. The overall prevalence of fatty liver among individuals with type 2 diabetes was found to be 50.3%. Age, duration of diabetes, hypertension and HbA1c levels appeared to have no impact on the prevalence of NAFLD. The possible predictors of NAFLD were overweight, obesity, central obesity, high triglyceride level and low high-density lipoprotein cholesterol (HDL-c) level. A higher prevalence of NAFLD was observed in individuals with three components of the metabolic syndrome. CONCLUSION: NAFLD was observed in half of the diabetic population, and its occurrence correlates positively with metabolic syndrome risk factors.
Authors: Britney E Graham; Christian Darabos; Minjun Huang; Louis J Muglia; Jason H Moore; Scott M Williams Journal: Genet Epidemiol Date: 2017-09-25 Impact factor: 2.135
Authors: Abdul Sattar Arif Khammas; Hasyma Abu Hassan; Sarah Qahtan M Salih; Hayati Kadir; Ramlah Mohamad Ibrahim; Nurul Nadiah Mohamad Nasir; Rozi Mahmud Journal: Porto Biomed J Date: 2018-09-19
Authors: Mohamed H Ahmed; Sufian K Noor; Sarra O Bushara; Nazik Elmalaika Husain; Wadie M Elmadhoun; Ibrahim A Ginawi; Meissa M Osman; Abdalhafeez O Mahmoud; Ahmed O Almobarak Journal: Gastroenterology Res Date: 2017-10-26