| Literature DB >> 26173940 |
Alessio Provenzani1, Manuela Labbozzetta2, Monica Notarbartolo2, Paola Poma2, Piera Polidori3, Giovanni Vizzini4, Natale D'Alessandro2.
Abstract
CASE (DESCRIPTION): We report the case of a 38-year-old woman treated with lamotrigine who experienced multi-organ dysfunction. The patient received the drug at the dose of 100 mg per day. One week later, the treatment was suspended because of an extensive body rash. Twenty-four hours later, the patient appeared drowsy and stuporous and was hospitalized. On the fifth day, the patient was admitted with a clinical picture of acute multi-organ failure in our Institute, where, she, despite the support of vital functions with vasoactive drugs, continuous hemofiltration and ventilation with oxygen, died. Serum lamotrigine concentration was measured 110 h after its last dose and the drug resulted to be still present at 1 mg/L. The patient was homozygous for the UGT1A4-70C and UGT2B7-161C alleles and heterozygous for the UGT2B7-372A>G polymorphism. Regarding ABCB1 the patient showed the 3435CC, 2677GT and 1236CT genotypes.Entities:
Keywords: ABCB1; Antiepileptic drugs; HLA; Lamotrigine; Multi-organ dysfunction; Pharmacogenetics; Rash; SNPs; UGT1A4; UGT2B7
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Year: 2015 PMID： 26173940 DOI： 10.1007/s11096-015-0158-4
Source DB: PubMed Journal: Int J Clin Pharm