Marije R Benedictus1, Argonde C van Harten2, Annebet E Leeuwis2, Teddy Koene2, Philip Scheltens2, Frederik Barkhof2, Niels D Prins2, Wiesje M van der Flier2. 1. From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. M.Benedictus@vumc.nl. 2. From the Alzheimer Center and Department of Neurology (M.R.B., A.C.v.H., A.E.L., P.S., N.D.P., W.M.v.d.F.), Department of Radiology and Nuclear Medicine (F.B.), Department of Medical Psychology (T.K.), and Department of Epidemiology and Biostatistics (W.M.v.d.F.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Abstract
BACKGROUND AND PURPOSE: In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline. METHODS: We included 334 patients with subjective cognitive decline. Follow-up was 3±2 years. RESULTS: Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline. CONCLUSIONS: In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.
BACKGROUND AND PURPOSE: In patients with subjective cognitive decline, we assessed whether small vessel disease was associated with clinical progression and cognitive decline. METHODS: We included 334 patients with subjective cognitive decline. Follow-up was 3±2 years. RESULTS: Fifty-three (16%) patients progressed clinically to mild cognitive impairment or dementia. White matter hyperintensities were associated with clinical progression and with annual decline on memory, attention, executive functioning, and global cognition. Microbleeds and lacunes were not associated with clinical progression or cognitive decline. CONCLUSIONS: In patients with subjective cognitive decline, patients with white matter hyperintensities are at increased risk of clinical progression and cognitive decline.
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