| Literature DB >> 26173415 |
Xueming Tan1, Xiaolu He2, Zhonghua Jiang3, Xiaohong Wang4, Limei Ma5, Li Liu6, Xiang Wang7, Zhining Fan8, Dongming Su9.
Abstract
Derlin-1 is overexpressed in many types of solid tumors and plays an important role in cancer progression. However, the expression pattern and functions of Derlin-1 in human colon cancer are not fully understood. In the present study, we examined Derlin-1 expression in colon cancer cell lines and human tissues and investigated its role in colon cancer. We found that Derlin-1 expression was increased significantly in colon cancer tissues and its overexpression correlated with the tumor differentiation, Dukes stage, invasion, lymph node metastasis, distant metastasis, and poor overall survival. The silencing of Derlin-1 by shRNA led to the growth inhibition of colon cancer cells, which were associated with the promotion of apoptosis. Furthermore, Derlin-1 silencing significantly inhibited the activation of the PI3K/AKT signaling pathway. Taken together, our results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells. Derlin-1 may be a potential therapeutic target for the treatment of colon cancer.Entities:
Keywords: Apoptosis; Derlin-1; Human colon cancer; Proliferation
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Year: 2015 PMID： 26173415 DOI： 10.1007/s11010-015-2496-x
Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396