Shiran S Moore 1,2 , Hilla Bahat 2,3 , Mariana Rachmiel 2,3 , Tomer Ziv-Baran 4 , Ilan Youngster 2,3 , Michael Goldman 2,3 Show Affiliations »
Abstract
AIM: Febrile urinary tract infections (UTIs) may be associated with long-term renal damage. Our goal was to identify risk factors for future UTIs in children who had voiding cystourethrography (VCUG) as a part of an antenatal hydronephrosis (ANH) assessment or after a febrile UTI. METHODS: We conducted a cohort study based on the medical records of children aged 0-24 months who underwent a VCUG between January 2004 and December 2011 and had at least six months of follow-up. The incidence of future UTIs was assessed. RESULTS: We included 285 children: 176 had a primary UTI and 109 had ANH. We recorded 28 UTIs during the follow-up period, and the risk was 12.5% after a primary UTI and 5.5% after an ANH (p = 0.049). Multivariate analysis showed no risk difference was found between the groups. Females had a greater risk of febrile UTIs (hazard ratio 3.3, 95% confidence interval 1.03-9.2, p = 0.04), but the UTI risk did not differ between children with or without VURs. CONCLUSION: Female infants were at greater risk of febrile UTIs, regardless of the presence of VUR, VUR degree, ANH or a previous UTI. Clinical guidelines for UTI and ANH assessment should preferably be gender specific. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
AIM: Febrile urinary tract infections (UTIs) may be associated with long-term renal damage . Our goal was to identify risk factors for future UTIs in children who had voiding cystourethrography (VCUG) as a part of an antenatal hydronephrosis (ANH) assessment or after a febrile UTI. METHODS: We conducted a cohort study based on the medical records of children aged 0-24 months who underwent a VCUG between January 2004 and December 2011 and had at least six months of follow-up. The incidence of future UTIs was assessed. RESULTS: We included 285 children : 176 had a primary UTI and 109 had ANH. We recorded 28 UTIs during the follow-up period, and the risk was 12.5% after a primary UTI and 5.5% after an ANH (p = 0.049). Multivariate analysis showed no risk difference was found between the groups. Females had a greater risk of febrile UTIs (hazard ratio 3.3, 95% confidence interval 1.03-9.2, p = 0.04), but the UTI risk did not differ between children with or without VURs. CONCLUSION: Female infants were at greater risk of febrile UTIs, regardless of the presence of VUR, VUR degree, ANH or a previous UTI. Clinical guidelines for UTI and ANH assessment should preferably be gender specific. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Entities: Disease
Species
Keywords:
Antenatal hydronephrosis; Renal scaring; Urinary tract infection; Vesicoureteral reflux; Voiding cystourethrography
Mesh： See more »
Year: 2015
PMID： 26173376 DOI： 10.1111/apa.13129
Source DB: PubMed Journal: Acta Paediatr ISSN： 0803-5253 Impact factor: 2.299