Edward J Casswell1, Edward Pringle2, Caroline Thuang3, Mike D Sanders4, Elizabeth M Graham5. 1. a Western Eye Hospital , London , UK . 2. b Kings College Hospital , London , UK . 3. c Department of Ocular Biology and Therapeutics , UCL Institute of Ophthalmology , London , UK . 4. d National Hospital of Neurology & Neurosurgery, Queen's Square , London , UK , and. 5. e St Thomas' Hospital , London , UK.
Abstract
PURPOSE: Paraneoplastic ocular inflammation can be associated with the autoantibody against collapsin response-mediator protein-5 (anti-CRMP-5). We describe the clinical and histological features of 2 rare cases of small cell lung carcinoma (SCLC) presenting with intraocular inflammation: the first was anti-CRMP-5 positive and the second preceded the auto-antibody's discovery but with remarkably similar features. The previously unreported retinal histology is described. METHODS: Case notes review. RESULTS: Both cases presented with bilateral visual loss, constricted visual fields, vitritis, and pale, swollen optic discs. Fundal fluorescein angiographies showed optic disc leakage. Retinal histology of both cases revealed predominantly inner retinal inflammation. Following their diagnosis with SCLC, serology for case 1 was positive for anti-CRMP-5 but case 2 pre-dated its discovery. CONCLUSIONS: CRMP-5 inflammatory eye disease presents with a distinct pattern of clinical and histological features, which may be the first sign of their underlying cancer. Retinal histology revealed predominantly inner retinal inflammation.
PURPOSE:Paraneoplastic ocular inflammation can be associated with the autoantibody against collapsin response-mediator protein-5 (anti-CRMP-5). We describe the clinical and histological features of 2 rare cases of small cell lung carcinoma (SCLC) presenting with intraocular inflammation: the first was anti-CRMP-5 positive and the second preceded the auto-antibody's discovery but with remarkably similar features. The previously unreported retinal histology is described. METHODS: Case notes review. RESULTS: Both cases presented with bilateral visual loss, constricted visual fields, vitritis, and pale, swollen optic discs. Fundal fluorescein angiographies showed optic disc leakage. Retinal histology of both cases revealed predominantly inner retinal inflammation. Following their diagnosis with SCLC, serology for case 1 was positive for anti-CRMP-5 but case 2 pre-dated its discovery. CONCLUSIONS:CRMP-5inflammatory eye disease presents with a distinct pattern of clinical and histological features, which may be the first sign of their underlying cancer. Retinal histology revealed predominantly inner retinal inflammation.
Entities:
Keywords:
CRMP-5; histology; inflammation; paraneoplastic; visual loss
Authors: Laura Hernández-Bel; Francisco Puchades-Gimeno; Amaya Fernandez-Diaz; Lucía Mata-Moret; Emma Beltrán-Catalán; María Luísa Hernandez-Garfella; Enrique Cervera-Taulet Journal: Rom J Ophthalmol Date: 2020 Apr-Jun