BACKGROUND: Transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC) is an important option as the majority of patients present with advanced disease. Data regarding treatment outcomes in patients who have undergone transjugular intrahepatic portosystemic shunts (TIPS) are limited. The present study seeks to evaluate the safety and efficacy of TACE in HCC patients with a TIPS. METHODS: A retrospective review identifying patients with HCC and concomitant TIPS who were treated with TACE was performed. RESULTS: From 1999 to 2014, 16 patients with HCC underwent a total of 27 TACE procedures; eight patients required multiple treatments. The median patient age at the time of the initial TACE was 60.5 years [interquartile range (IQR) : 52.5-67.5] with the majority being male (n = 12, 75%) and Childs-Pugh Class B (n = 12, 75%). At 6 weeks after TACE, 56.3% of patients achieved an objective response rate (complete and partial response) by mRECIST criteria. Clavien Grade 3 or higher complications occurred in 11.1% of TACE procedures. There were no peri-procedural deaths. The median progression-free (PFS) and overall survival (OS) were 9 and 22 months, respectively, when censored for liver transplantation (median follow-up: 11.5 months). CONCLUSION: TACE is an effective treatment strategy for HCC in TIPS patients; albeit may be associated with higher complication rates.
BACKGROUND: Transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC) is an important option as the majority of patients present with advanced disease. Data regarding treatment outcomes in patients who have undergone transjugular intrahepatic portosystemic shunts (TIPS) are limited. The present study seeks to evaluate the safety and efficacy of TACE in HCCpatients with a TIPS. METHODS: A retrospective review identifying patients with HCC and concomitant TIPS who were treated with TACE was performed. RESULTS: From 1999 to 2014, 16 patients with HCC underwent a total of 27 TACE procedures; eight patients required multiple treatments. The median patient age at the time of the initial TACE was 60.5 years [interquartile range (IQR) : 52.5-67.5] with the majority being male (n = 12, 75%) and Childs-Pugh Class B (n = 12, 75%). At 6 weeks after TACE, 56.3% of patients achieved an objective response rate (complete and partial response) by mRECIST criteria. Clavien Grade 3 or higher complications occurred in 11.1% of TACE procedures. There were no peri-procedural deaths. The median progression-free (PFS) and overall survival (OS) were 9 and 22 months, respectively, when censored for liver transplantation (median follow-up: 11.5 months). CONCLUSION: TACE is an effective treatment strategy for HCC in TIPS patients; albeit may be associated with higher complication rates.
Authors: Maxim Itkin; Scott O Trerotola; S William Stavropoulos; Aalpen Patel; Jeffrey I Mondschein; Michael C Soulen; Catherine M Tuite; Richard D Shlansky-Goldberg; Thomas W Faust; K Rajender Reddy; Jeffrey A Solomon; Timothy W I Clark Journal: J Vasc Interv Radiol Date: 2006-01 Impact factor: 3.464
Authors: Daniel B Brown; William C Chapman; Ryan D Cook; Jason R Kerr; Jennifer E Gould; Thomas K Pilgram; Michael D Darcy Journal: AJR Am J Roentgenol Date: 2008-03 Impact factor: 3.959
Authors: Yuo-Chen Kuo; Maureen P Kohi; David M Naeger; Ricky T Tong; K Pallav Kolli; Andrew G Taylor; Jeanne M Laberge; Robert K Kerlan; Nicholas Fidelman Journal: Cardiovasc Intervent Radiol Date: 2013-07-18 Impact factor: 2.740
Authors: Maureen P Kohi; Nicholas Fidelman; David M Naeger; Jeanne M LaBerge; Roy L Gordon; Robert K Kerlan Journal: J Vasc Interv Radiol Date: 2012-11-22 Impact factor: 3.464
Authors: Tushar Garg; Apurva Shrigiriwar; Peiman Habibollahi; Mircea Cristescu; Robert P Liddell; Julius Chapiro; Peter Inglis; Juan C Camacho; Nariman Nezami Journal: Cancers (Basel) Date: 2022-07-10 Impact factor: 6.575