| Literature DB >> 26170190 |
Abstract
The transcription factor forkhead box O1 (FoxO1) plays pleiotropic roles in insulin-mediated glucose and lipid metabolism. In the liver, glucose production is finely controlled by insulin signaling that dampens FoxO1. Two recent studies show that silencing of FoxO1 is also essential for extra-hepatic insulin signaling to maintain glucose homeostasis.Entities:
Keywords: FoxO1; glucose; insulin resistance; insulin signaling; lipid; metabolic homeostasis
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Year: 2015 PMID： 26170190 DOI： 10.1016/j.tem.2015.06.006
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015