Arman Abrahamyan1, Colin W G Clifford2, Ehsan Arabzadeh3, Justin A Harris4. 1. School of Psychology, University of Sydney, Australia; Lab for Human Systems Neuroscience, RIKEN Brain Science Institute, Japan. Electronic address: arman@brain.riken.jp. 2. School of Psychology, University of Sydney, Australia; School of Psychology, University of New South Wales, Australia. 3. School of Psychology, University of Sydney, Australia; Eccles Institute of Neuroscience, The John Curtin School of Medical Research, Australian National University, Australia. 4. School of Psychology, University of Sydney, Australia.
Abstract
BACKGROUND: Transcranial magnetic stimulation (TMS) is a popular functional mapping tool in cognitive and sensory neuroscience. While strong TMS typically degrades performance, two recent studies have demonstrated that weak TMS, delivered to visual cortex, can improve performance on simple visual tasks. The improvement was interpreted as the summation of visually-evoked and TMS-elicited neuronal activity in visual cortex, but the nature of this interaction remains unclear. OBJECTIVE: The present experiments sought to determine whether these weak pulses of TMS assist subjects to see the visual stimulus itself or create a distinct "melded" percept that may not be recognizable as the visual stimulus. METHODS: We measured contrast thresholds in an orientation discrimination task in which participants reported the orientation (left or right) of gratings tilted 45° from vertical. RESULTS: Weak TMS improved sensitivity for identifying gratings, suggesting that TMS sums with but preserves orientation information so that the subject can recognize the visual stimulus. We explain the effect using a mechanism of non-linear transduction of sensory signals in the brain. CONCLUSIONS: The capability of low-intensity TMS to augment the neural signal while preserving information encoded in the stimulus can be employed as a novel approach to study the neural correlates of consciousness by selectively "pushing" an unconscious stimulus into consciousness.
BACKGROUND: Transcranial magnetic stimulation (TMS) is a popular functional mapping tool in cognitive and sensory neuroscience. While strong TMS typically degrades performance, two recent studies have demonstrated that weak TMS, delivered to visual cortex, can improve performance on simple visual tasks. The improvement was interpreted as the summation of visually-evoked and TMS-elicited neuronal activity in visual cortex, but the nature of this interaction remains unclear. OBJECTIVE: The present experiments sought to determine whether these weak pulses of TMS assist subjects to see the visual stimulus itself or create a distinct "melded" percept that may not be recognizable as the visual stimulus. METHODS: We measured contrast thresholds in an orientation discrimination task in which participants reported the orientation (left or right) of gratings tilted 45° from vertical. RESULTS: Weak TMS improved sensitivity for identifying gratings, suggesting that TMS sums with but preserves orientation information so that the subject can recognize the visual stimulus. We explain the effect using a mechanism of non-linear transduction of sensory signals in the brain. CONCLUSIONS: The capability of low-intensity TMS to augment the neural signal while preserving information encoded in the stimulus can be employed as a novel approach to study the neural correlates of consciousness by selectively "pushing" an unconscious stimulus into consciousness.
Authors: Florian Herpich; Michael D Melnick; Sara Agosta; Krystel R Huxlin; Duje Tadin; Lorella Battelli Journal: J Neurosci Date: 2019-05-27 Impact factor: 6.167
Authors: Olga Lucia Gamboa Arana; Hannah Palmer; Moritz Dannhauer; Connor Hile; Sicong Liu; Rena Hamdan; Alexandra Brito; Roberto Cabeza; Simon W Davis; Angel V Peterchev; Marc A Sommer; Lawrence G Appelbaum Journal: Neuropsychologia Date: 2020-08-12 Impact factor: 3.139