Nihat Demir1, Erdal Peker1, İbrahim Ece2, Kemal Ağengin3, Keziban Asli Bulan4, Oğuz Tuncer1. 1. a Department of Pediatrics, Division of Neonatology . 2. b Department of Pediatrics, Division of Cardiology . 3. c Department of Pediatric Surgery , and. 4. d Department of Pediatrics, Division of Endocrinology , Yuzuncu Yil University School of Medicine , Van , Turkey.
Abstract
BACKGROUND: The purpose of this study was to evaluate whether or not platelet mass contributes to closure of patent ductus arteriosus (PDA) in premature newborns. STUDY DESIGN AND SUBJECTS: This retrospective study included 115 preterm newborns with hemodynamically significant PDA (hPDA) and 120 newborns without PDA. The newborns' platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) were noted from their files and the platelet mass (platelet count plus MPV/10(3)) was calculated. Patients with congenital abnormality, persistent pulmonary hypertension or sepsis were not included in the study. RESULTS: Platelet count and PDW were found to not be risk factors for closure of hPDA (p > 0.05), but both high platelet mass (OR 1.25; 95% CI 1.12-1.41) and MPV (OR 1.87; 95% CI 2.52-3.85) were determined to be independent risk factors for hPDA. CONCLUSIONS: Platelet mass may be a more significant indicator than platelet count of closure of hPDA in preterm newborns.
BACKGROUND: The purpose of this study was to evaluate whether or not platelet mass contributes to closure of patent ductus arteriosus (PDA) in premature newborns. STUDY DESIGN AND SUBJECTS: This retrospective study included 115 preterm newborns with hemodynamically significant PDA (hPDA) and 120 newborns without PDA. The newborns' platelet count, mean platelet volume (MPV) and platelet distribution width (PDW) were noted from their files and the platelet mass (platelet count plus MPV/10(3)) was calculated. Patients with congenital abnormality, persistent pulmonary hypertension or sepsis were not included in the study. RESULTS: Platelet count and PDW were found to not be risk factors for closure of hPDA (p > 0.05), but both high platelet mass (OR 1.25; 95% CI 1.12-1.41) and MPV (OR 1.87; 95% CI 2.52-3.85) were determined to be independent risk factors for hPDA. CONCLUSIONS: Platelet mass may be a more significant indicator than platelet count of closure of hPDA in preterm newborns.
Authors: Hannes Sallmon; Sven C Weber; Juliane Dirks; Tamara Schiffer; Tamara Klippstein; Anja Stein; Ursula Felderhoff-Müser; Boris Metze; Georg Hansmann; Christoph Bührer; Malte Cremer; Petra Koehne Journal: Front Pediatr Date: 2018-03-07 Impact factor: 3.418
Authors: Hannes Sallmon; Natalie Timme; Begüm Atasay; Ömer Erdeve; Georg Hansmann; Yogen Singh; Sven C Weber; Elaine L Shelton Journal: Front Pediatr Date: 2021-02-25 Impact factor: 3.418