Literature DB >> 26169607

Expanding intestinal stem cells in culture.

Inha Heo1, Hans Clevers1.   

Abstract

Culturing intestinal stem cells into 3D organoids results in heterogeneous cell populations, reflecting the in vivo cell type diversity. In a recent paper published in Nature, Wang et al. established a culture condition for a highly homogeneous population of intestinal stem cells.

Mesh：

Year:  2015        PMID： 26169607      PMCID： PMC4559810          DOI： 10.1038/cr.2015.83

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  9 in total

1.  Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.

Authors:  Shiro Yui; Tetsuya Nakamura; Toshiro Sato; Yasuhiro Nemoto; Tomohiro Mizutani; Xiu Zheng; Shizuko Ichinose; Takashi Nagaishi; Ryuichi Okamoto; Kiichiro Tsuchiya; Hans Clevers; Mamoru Watanabe
Journal:  Nat Med       Date:  2012-03-11       Impact factor: 53.440

2.  Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Authors:  Toshiro Sato; Robert G Vries; Hugo J Snippert; Marc van de Wetering; Nick Barker; Daniel E Stange; Johan H van Es; Arie Abo; Pekka Kujala; Peter J Peters; Hans Clevers
Journal:  Nature       Date:  2009-03-29       Impact factor: 49.962

Review 3.  Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications.

Authors:  Toshiro Sato; Hans Clevers
Journal:  Science       Date:  2013-06-07       Impact factor: 47.728

4.  Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium.

Authors:  Toshiro Sato; Daniel E Stange; Marc Ferrante; Robert G J Vries; Johan H Van Es; Stieneke Van den Brink; Winan J Van Houdt; Apollo Pronk; Joost Van Gorp; Peter D Siersema; Hans Clevers
Journal:  Gastroenterology       Date:  2011-09-02       Impact factor: 22.682

5.  Isolation and in vitro expansion of human colonic stem cells.

Authors:  Peter Jung; Toshiro Sato; Anna Merlos-Suárez; Francisco M Barriga; Mar Iglesias; David Rossell; Herbert Auer; Mercedes Gallardo; Maria A Blasco; Elena Sancho; Hans Clevers; Eduard Batlle
Journal:  Nat Med       Date:  2011-09-04       Impact factor: 53.440

6.  Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny.

Authors:  Xiaolei Yin; Henner F Farin; Johan H van Es; Hans Clevers; Robert Langer; Jeffrey M Karp
Journal:  Nat Methods       Date:  2013-12-01       Impact factor: 28.547

7.  Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

Authors:  Henner F Farin; Johan H Van Es; Hans Clevers
Journal:  Gastroenterology       Date:  2012-08-23       Impact factor: 22.682

8.  Adult stem cells in the small intestine are intrinsically programmed with their location-specific function.

Authors:  Sabine Middendorp; Kerstin Schneeberger; Caroline L Wiegerinck; Michal Mokry; Ronald D L Akkerman; Simone van Wijngaarden; Hans Clevers; Edward E S Nieuwenhuis
Journal:  Stem Cells       Date:  2014-05       Impact factor: 6.277

9.  Cloning and variation of ground state intestinal stem cells.

Authors:  Xia Wang; Yusuke Yamamoto; Lane H Wilson; Ting Zhang; Brooke E Howitt; Melissa A Farrow; Florian Kern; Gang Ning; Yue Hong; Chiea Chuen Khor; Benoit Chevalier; Denis Bertrand; Lingyan Wu; Niranjan Nagarajan; Francisco A Sylvester; Jeffrey S Hyams; Thomas Devers; Roderick Bronson; D Borden Lacy; Khek Yu Ho; Christopher P Crum; Frank McKeon; Wa Xian
Journal:  Nature       Date:  2015-06-03       Impact factor: 49.962
  9 in total
  4 in total

Review 1.  Mechanisms of intestinal adaptation.

Authors:  Deborah C Rubin; Marc S Levin
Journal:  Best Pract Res Clin Gastroenterol       Date:  2016-03-16       Impact factor: 3.043

Review 2.  Chemoprevention of hereditary colon cancers: time for new strategies.

Authors:  Luigi Ricciardiello; Dennis J Ahnen; Patrick M Lynch
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2016-04-20       Impact factor: 46.802

Review 3.  TGFβ-Directed Therapeutics: 2020.

Authors:  Beverly A Teicher
Journal:  Pharmacol Ther       Date:  2020-08-21       Impact factor: 12.310

Review 4.  CRISPR therapeutic tools for complex genetic disorders and cancer (Review).

Authors:  Stella Baliou; Maria Adamaki; Anthony M Kyriakopoulos; Demetrios A Spandidos; Mihalis Panayiotidis; Ioannis Christodoulou; Vassilis Zoumpourlis
Journal:  Int J Oncol       Date:  2018-06-06       Impact factor: 5.650
  4 in total

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