Kristin A Evans1, David Q Rich2, Barry Weinberger3, Anna M Vetrano3, Liza Valentin-Blasini4, Pamela Ohman Strickland5, Benjamin C Blount4. 1. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address: Kristin_Evans@urmc.rochester.edu. 2. Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. 3. Division of Neonatology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA. 4. Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA, USA. 5. Department of Biostatistics, School of Public Health, Rutgers University, Piscataway, NJ, USA.
Abstract
BACKGROUND: Perchlorate and similar anions compete with iodine for uptake into the thyroid by the sodium iodide symporter (NIS). This may restrict fetal growth via impaired thyroid hormone production. METHODS: We collected urine samples from 107 pregnant women and used linear regression to estimate differences in newborn size and gestational age associated with increases in perchlorate, thiocyanate, nitrate, and perchlorate equivalence concentrations (PEC; measure of total NIS inhibitor exposure). RESULTS: NIS inhibitor concentrations were not associated with newborn weight, length, or gestational age. Each 2.62ng/μg creatinine increase in perchlorate was associated with smaller head circumference (0.32cm; 95% CI: -0.66, 0.01), but each 3.38ng/μg increase in PEC was associated with larger head circumference (0.48cm; -0.01, 0.97). CONCLUSIONS: These anions may have effects on fetal development (e.g. neurocognitive) that are not reflected in gross measures. Future research should focus on other abnormalities in neonates exposed to NIS inhibitors.
BACKGROUND:Perchlorate and similar anions compete with iodine for uptake into the thyroid by the sodium iodide symporter (NIS). This may restrict fetal growth via impaired thyroid hormone production. METHODS: We collected urine samples from 107 pregnant women and used linear regression to estimate differences in newborn size and gestational age associated with increases in perchlorate, thiocyanate, nitrate, and perchlorate equivalence concentrations (PEC; measure of total NIS inhibitor exposure). RESULTS:NIS inhibitor concentrations were not associated with newborn weight, length, or gestational age. Each 2.62ng/μg creatinine increase in perchlorate was associated with smaller head circumference (0.32cm; 95% CI: -0.66, 0.01), but each 3.38ng/μg increase in PEC was associated with larger head circumference (0.48cm; -0.01, 0.97). CONCLUSIONS: These anions may have effects on fetal development (e.g. neurocognitive) that are not reflected in gross measures. Future research should focus on other abnormalities in neonates exposed to NIS inhibitors.
Authors: Sarah Timmermans; Régine P Steegers-Theunissen; Marijana Vujkovic; Hanneke den Breeijen; Henk Russcher; Jan Lindemans; Johan Mackenbach; Albert Hofman; Emmanuel E Lesaffre; Vincent V Jaddoe; Eric A Steegers Journal: Br J Nutr Date: 2012-02-21 Impact factor: 3.718
Authors: Rebecca A Clewell; Elaine A Merrill; Kyung O Yu; Deirdre A Mahle; Teresa R Sterner; David R Mattie; Peter J Robinson; Jeffrey W Fisher; Jeffery M Gearhart Journal: Toxicol Sci Date: 2003-04-15 Impact factor: 4.849
Authors: Neil Tran; Liza Valentín-Blasini; Benjamin C Blount; Caroline Gibbs McCuistion; Mike S Fenton; Eric Gin; Andrew Salem; Jerome M Hershman Journal: Am J Physiol Endocrinol Metab Date: 2008-02-26 Impact factor: 4.310
Authors: Patricia A Buffler; Michael A Kelsh; Edmund C Lau; Charlotte H Edinboro; Julie C Barnard; George W Rutherford; Jorge J Daaboul; Lynn Palmer; Fred W Lorey Journal: Environ Health Perspect Date: 2006-05 Impact factor: 9.031
Authors: Rainbow Rubin; Michelle Pearl; Martin Kharrazi; Benjamin C Blount; Mark D Miller; Elizabeth N Pearce; Liza Valentin-Blasini; Gerald DeLorenze; Jane Liaw; Andrew N Hoofnagle; Craig Steinmaus Journal: Environ Res Date: 2017-06-09 Impact factor: 6.498
Authors: Bridget A Knight; Beverley M Shields; Xuemei He; Elizabeth N Pearce; Lewis E Braverman; Rachel Sturley; Bijay Vaidya Journal: Thyroid Res Date: 2018-07-06